Results 81 to 90 of about 2,444,475 (338)

Current status of direct dark matter detection experiments [PDF]

open access: yesNature Physics, 2017
6 pages, 4 figures, version accepted by Nature ...
Jianglai Liu, Xun Chen, Xiangdong Ji
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

2D/3D Perovskite Surface Passivation-Enabled High-Detectivity Near-Infrared Photodiodes

open access: yesSensors
Due to high responsivity and wide spectral sensitivity, metal halide perovskite photodiodes have a wide range of applications in the fields of visible light and near-infrared photodetection.
Xuefeng Huangfu   +7 more
doaj   +1 more source

The Drafting of the Housing Legislation [PDF]

open access: yes, 1934
This diploma project has been focused on optimization of the D2B IR detector fabrication process using different mesa sidewall treatments and passivation methods. X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and atomic force
Chase, Ralph K.
core   +1 more source

Dark energy and dark matter from cosmological observations

open access: yes, 2005
The present status of our knowledge about the dark matter and dark energy is reviewed. Bounds on the content of cold and hot dark matter from cosmological observations are discussed in some detail.
Alam U.   +9 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Overview of Non-Liquid Noble Direct Detection Dark Matter Experiments

open access: yes, 2014
In the last few years many advances have been made in the field of dark matter direct detection. In this article I will review the progress and status of experiments that employ detection techniques that do not use noble liquids.
Cooley, J.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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