Results 101 to 110 of about 917,675 (340)

Dark Matters on the Scale of Galaxies

Universe, 2020
The cold dark-matter model successfully explains both the emergence and evolution of cosmic structures on large scales and, when we include a cosmological constant, the properties of the homogeneous and isotropic Universe.
Ivan de Martino, Sankha S. Chakrabarty, Valentina Cesare, Arianna Gallo, Luisa Ostorero, Antonaldo Diaferio   +5 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Time delay of light in the gravitational lensing of supermassive black holes in dark matter halos

European Physical Journal C: Particles and Fields
The dark matter halo has non-negligible effects on the gravitational lensing of supermassive black hole in the galaxy center. Our work presents a study on the time-delay of light in gravitational lensing of black holes enclosed by dark matter halos.
Chen-Kai Qiao, Ping Su
doaj   +1 more source

Emergent dark matter in late time universe on holographic screen

Journal of High Energy Physics, 2018
We discuss a scenario that the dark matter in late time universe emerges as part of the holographic stress-energy tensor on the hypersurface in higher dimensional flat spacetime.
Rong-Gen Cai, Sichun Sun, Yun-Long Zhang
doaj   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

The spatial distribution of dark-matter-annihilation originated gamma-ray line signal

, 2013
The GeV$-$TeV $\gamma-$ray line signal is the smoking gun signature of the dark matter annihilation or decay. The detection of such a signal is one of the main targets of some space-based telescopes, including Fermi-LAT and the upcoming CALET, DAMPE and ...
Dong, Tie-Kuang, Lu, Tong-Suo, Wu, Jian
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Dark matter distribution in dwarf spheroidal galaxies [PDF]

Monthly Notices of the Royal Astronomical Society, 2002
We study the distribution of dark matter in dwarf spheroidal galaxies by modelling the moments of their line-of-sight velocity distributions. We discuss different dark matter density profiles, both cuspy and possessing flat density cores. The predictions are made in the framework of standard dynamical theory of two-component (stars and dark matter ...
openaire   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source