Results 81 to 90 of about 917,675 (340)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
, 2004 The evolution of the dark matter distribution at the Galactic center is analyzed, which is caused by the combination of gravitational scattering on Galactic bulge stars and absorption by a supermassive black hole at the center of the bulge.
A. Lightman +7 more
core +2 more sources
A Dense Dark Matter Core of the Subhalo in the Strong Lensing System JVAS B1938+666
The Astrophysical Journal LettersThe nature of dark matter remains unknown, motivating the study of fuzzy/wave dark matter (FDM/ ψ DM) and self-interacting dark matter (SIDM) as alternative frameworks to address small-scale discrepancies in halo profiles inferred from observations. This
Lei Lei +9 more
doaj +1 more source
Dark Matter Signals in the gamma-ray sky
EPJ Web of Conferences, 2014 Detection of gamma rays and cosmic rays from the annihilation or decay of dark matter particles is a promising method for identifying dark matter, understanding its intrinsic properties, and mapping its distribution in the universe.
Morselli Aldo
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Astrophysical JournalWe present Multi-resolution MAximum-entropy Reconstruction Technique Integrating Analytic Node ( MrMARTIAN ), a new hybrid strong lensing (SL) modeling algorithm.
Sangjun Cha, M. James Jee
doaj +1 more source
Probing multicomponent extension of inert doublet model with a vector dark matter
European Physical Journal C: Particles and Fields, 2019 Although theoretically well-motivated as a minimal consistent dark matter (DM) model, the inert doublet model (IDM) fell short in explaining the existence of DM in the intermediate mass region (100–500 GeV).
Sreemanti Chakraborti +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dark Matter Direct Detection with Non-Maxwellian Velocity Structure [PDF]
, 2009 The velocity distribution function of dark matter particles is expected to show significant departures from a Maxwell-Boltzmann distribution. This can have profound effects on the predicted dark matter - nucleon scattering rates in direct detection ...
A. Katz +33 more
core +1 more source
Particle dark matter searches in the anisotropic sky
Frontiers in Physics, 2014 Anisotropies in the electromagnetic emission produced by dark matter annihilation or decay in the extragalactic sky are a recent tool in the quest for a particle dark matter evidence.
Nicolao eFornengo +3 more
doaj +1 more source