Results 101 to 110 of about 1,616,838 (296)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Substructure depletion in the Milky Way halo by the disk

, 2009
We employ numerical simulations and simple analytical estimates to argue that dark matter substructures orbiting in the inner regions of the Galaxy can be efficiently destroyed by disk shocking, a dynamical process known to affect globular star clusters.
Abadi, Angulo, Binney, Bryan, D'Onghia, D'Onghia, Debattista, Dubinski, Dusan Keres, Elena D'Onghia, Ghigna, Gnedin, Hayashi, Hopkins, Kazantzidis, Kazantzidis, Kazantzidis, Kereš, Klypin, Komatsu, Kuzmin, Lars Hernquist, Ludlow, Maccio', Martínez-Delgado, Moore, Muñoz, Navarro, Peñarrubia, Pieri, Springel, Taylor, Toomre, Volker Springel, White   +34 more
core   +1 more source

'Dark Patterns': The Case for Regulatory Pluralism

SSRN Electronic Journal, 2020
‘Dark patterns’ is a term commonly used by the web collective to describe a user interface that exploits users into doing something that they would not normally do. It is a coercive and manipulative design technique used by web designers when some sort of action is needed from a user - typically to begin the processing of personal data or indication of
openaire   +4 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Identifying Dark Patterns in User Account Disabling Interfaces: Content Analysis Results

Social Media + Society
Dark patterns are user interface (UI) strategies deliberately designed to influence users to perform actions or make choices that benefit online service providers. This mixed methods study examines dark patterns employed by social networking sites (SNSs)
Dominique Kelly, Victoria L. Rubin
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

New Interaction Patterns for the Truncated M-Fractional Kadomtsev–Petviashvili Equation in High-Dimensional Space

Fractal and Fractional
A truncated M-fractional Kadomtsev–Petviashvili (KP) equation in high-dimensional space has been proposed. The model provides the oretical support for studying the interaction patterns among waves.
Lihua Zhang, Shuqi Chong, Hongbing Jiao, Bo Shen, Gangwei Wang   +4 more
doaj   +1 more source

Dark Patterns ur ett företagsekonomiskt perspektiv : Dark Patterns påverkan på varumärkeslojalitet

, 2020
Bakgrunden till denna uppsats är det ökande intresset av olika designtekniker inom webbdesign. Ämnet som studeras växer och är något som de flesta individer i dagens samhälle kommer i kontakt med. Problemet ligger i att det potentiellt sett finns en baksida med att använda sig av denna typ av designelement.
Olsson, David, Jonsson, Christian
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source