Results 101 to 110 of about 3,890,266 (282)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The evolution of dark matter substructure [PDF]
, 2001 This thesis investigates the dynamical evolution of systems orbiting within deeper potentials. Initially we use a simple satellite-halo interaction to study the dynamical processes that act on orbiting systems and we compare these results to analytical ...
Roldán, Carlos Antonio Calcáneo
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dark Patterns as Disloyal Design [PDF]
Lawmakers have started to regulate “dark patterns,” understood to be design practices meant to influence technology users’ decisions through manipulative or deceptive means.
Choffnes, David +4 more
core +4 more sources
Identifying Dark Patterns in User Account Disabling Interfaces: Content Analysis Results
Social Media + SocietyDark patterns are user interface (UI) strategies deliberately designed to influence users to perform actions or make choices that benefit online service providers. This mixed methods study examines dark patterns employed by social networking sites (SNSs)
Dominique Kelly, Victoria L. Rubin
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Dark patterns in persuasive design. [PDF]
, 2021 Website designs often choose to use unethical designs for commercial purposes that mislead users into taking action. These specific solutions that act as psychological to consumers are called dark patterns, they are not designers mistakes, but well ...
Vizgirdaitė, Ieva,
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Fractal and FractionalA truncated M-fractional Kadomtsev–Petviashvili (KP) equation in high-dimensional space has been proposed. The model provides the oretical support for studying the interaction patterns among waves.
Lihua Zhang +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Dark patterns detection in e-commerce websites. [PDF]
, 2022 To get the most out of users, website owners often decide to use dark patterns in the design of their systems. Dark patterns – user interface that was carefully created to deceive the user into giving more information or buying more goods than intended ...
Anužas, Paulius,
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