Results 111 to 120 of about 1,616,838 (296)

Skyrmion-like excitations in dynamical lattices

, 2006
We construct discrete analogs of Skyrmions in nonlinear dynamical lattices. The Skyrmion is built as a vortex soliton of a complex field, coupled to a dark radial soliton of a real field.
B. A. Malomed, D. J. Frantzeskakis, D. K. Campbell, F. K. Diakonos, F. Wilczek, P. G. Kevrekidis, P. G. Kevrekidis, R. Carretero-González, R. Morandotti   +8 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Circadian rhythm of locomotor activity in Bothrops jararacussu (Serpentes: Viperidae) [PDF]

Biotemas, 2007
Many biochemical, physiological, and behavioral parameters exhibited by organisms show daily fluctuations, and most of these fluctuations persist when the organisms are maintained in constant environmental conditions, thus demonstrating that they are ...
José Geraldo Pereira da Cruz
doaj  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Dark Cycles: Social Engineering and Political Chatbots in Netanyahu’s 2019 Election Campaigns

International Journal of Communication
This study investigates the potential adverse effects of political chatbots operating as peer-to-peer propaganda tools that evade public and regulatory oversight.
Anat Ben-David, Elinor Carmi
doaj  

How People Recognize Dark Pattern in E-Commerce?

Jurnal Sistem Informasi
In the digital era, many manipulative design tactics, commonly referred to as ‘dark patterns’, have emerged. These tactics are designed to hide, mislead, deceive, and even exploit users while using an application.
Hafidza Safara Zahratunnisa, Imairi Etiveni, Betty Purwandari, Erisva Hakiki Purwaningsih   +3 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Examining the mechanisms linking Dark Triad traits to OCB through LMX and political skill: a comparative study of managerial and non-managerial levels

Frontiers in Psychology
PurposeThis study examines the relationship between perceived leaders’ Dark Triad personality traits (Machiavellianism, narcissism, and psychopathy) and followers’ organizational citizenship behavior (OCB). We explore how leader-member exchange (LMX) and
Abira Reizer, Aharon Tziner, Amos Drory
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source