Results 111 to 120 of about 3,890,266 (282)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Dark Cycles: Social Engineering and Political Chatbots in Netanyahu’s 2019 Election Campaigns

International Journal of Communication
This study investigates the potential adverse effects of political chatbots operating as peer-to-peer propaganda tools that evade public and regulatory oversight.
Anat Ben-David, Elinor Carmi
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Choices under manipulation: Cognitive processes and behavioral biases of older adults under perceived exposure to dark patterns in online shopping

Acta Psychologica
With the convergence of population aging and digitalization, more older adults are engaged in online shopping. However, the prevalence of dark patterns on digital platforms is associated with unintended consumption behaviors.
Ying Zhang, Chun-Fu Chen, Hui-Ling Hu
doaj   +1 more source

Circadian rhythm of locomotor activity in Bothrops jararacussu (Serpentes: Viperidae) [PDF]

Biotemas, 2007
Many biochemical, physiological, and behavioral parameters exhibited by organisms show daily fluctuations, and most of these fluctuations persist when the organisms are maintained in constant environmental conditions, thus demonstrating that they are ...
José Geraldo Pereira da Cruz
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

How People Recognize Dark Pattern in E-Commerce?

Jurnal Sistem Informasi
In the digital era, many manipulative design tactics, commonly referred to as ‘dark patterns’, have emerged. These tactics are designed to hide, mislead, deceive, and even exploit users while using an application.
Hafidza Safara Zahratunnisa, Imairi Etiveni, Betty Purwandari, Erisva Hakiki Purwaningsih   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Obesity drives temporally distinct physical activity disruptions in mice under a fixed 24-h light-dark cycle

Scientific Reports
24-h cycles regulate activity and feeding behavior, and obesity and metabolic dysfunction may disrupt such rhythms. Here, using a fixed 24-h light-dark cycle, we investigate sex-specific diurnal physical activity patterns in obese and normal weight mice.
Abigail Usiyevich, Yufan Li, Reema Sharma, Kenny Arbuckle, Jay Shah, Bridget A. Matikainen-Ankney   +5 more
doaj   +1 more source