Results 111 to 120 of about 540,061 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Learning from the Dark Side About How (not) to Engineer Privacy: Analysis of Dark Patterns Taxonomies from an ISO 29100 Perspective [PDF]

peer reviewedThe privacy engineering literature proposes requirements for the design of technologies but gives little guidance on how to correctly fulfil them in practice.
BOTES, Wilhelmina Maria, SERGEEVA, Anastasia, VALOGGIA, Philippe, ROSSI, Arianna   +3 more
core   +1 more source

Dark Cycles: Social Engineering and Political Chatbots in Netanyahu’s 2019 Election Campaigns

International Journal of Communication
This study investigates the potential adverse effects of political chatbots operating as peer-to-peer propaganda tools that evade public and regulatory oversight.
Anat Ben-David, Elinor Carmi
doaj  

Choices under manipulation: Cognitive processes and behavioral biases of older adults under perceived exposure to dark patterns in online shopping

Acta Psychologica
With the convergence of population aging and digitalization, more older adults are engaged in online shopping. However, the prevalence of dark patterns on digital platforms is associated with unintended consumption behaviors.
Ying Zhang, Chun-Fu Chen, Hui-Ling Hu
doaj   +1 more source

Circadian rhythm of locomotor activity in Bothrops jararacussu (Serpentes: Viperidae) [PDF]

Biotemas, 2007
Many biochemical, physiological, and behavioral parameters exhibited by organisms show daily fluctuations, and most of these fluctuations persist when the organisms are maintained in constant environmental conditions, thus demonstrating that they are ...
José Geraldo Pereira da Cruz
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Dark Patterns in the Travel Industry : A study on users’ perception of dark patterns on airline companies’ websites

, 2023
This thesis investigates how airline companies use dark patterns on their websites and how users perceive them. Dark patterns are deceiving design strategies that take advantage of users by integrating misleading user interface features to trick users ...
Holmberg, Ebba, Manse, Sarah
core  

How People Recognize Dark Pattern in E-Commerce?

Jurnal Sistem Informasi
In the digital era, many manipulative design tactics, commonly referred to as ‘dark patterns’, have emerged. These tactics are designed to hide, mislead, deceive, and even exploit users while using an application.
Hafidza Safara Zahratunnisa, Imairi Etiveni, Betty Purwandari, Erisva Hakiki Purwaningsih   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source