Results 111 to 120 of about 4,043,825 (280)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Choices under manipulation: Cognitive processes and behavioral biases of older adults under perceived exposure to dark patterns in online shopping

Acta Psychologica
With the convergence of population aging and digitalization, more older adults are engaged in online shopping. However, the prevalence of dark patterns on digital platforms is associated with unintended consumption behaviors.
Ying Zhang, Chun-Fu Chen, Hui-Ling Hu
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

How People Recognize Dark Pattern in E-Commerce?

Jurnal Sistem Informasi
In the digital era, many manipulative design tactics, commonly referred to as ‘dark patterns’, have emerged. These tactics are designed to hide, mislead, deceive, and even exploit users while using an application.
Hafidza Safara Zahratunnisa, Imairi Etiveni, Betty Purwandari, Erisva Hakiki Purwaningsih   +3 more
doaj   +1 more source

Robust light-dark patterns and reduced amyloid load in an Alzheimer's disease transgenic mouse model. [PDF]

Sci Rep, 2020
Nagare R, Possidente B, Lagalwar S, Figueiro MG.   +3 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Dark Patterns in Mobile Games

Investigating the prevalence of dark patterns in mobile free-to-play games, as well as the co-occurrence of different types of dark patterns. A dataset of video recordings of the first hour of gameplay of top-grossing mobile game was generated and used ...
Leon Y. Xiao, Minxing Wang, Zhiyu Chen
core   +1 more source

Obesity drives temporally distinct physical activity disruptions in mice under a fixed 24-h light-dark cycle

Scientific Reports
24-h cycles regulate activity and feeding behavior, and obesity and metabolic dysfunction may disrupt such rhythms. Here, using a fixed 24-h light-dark cycle, we investigate sex-specific diurnal physical activity patterns in obese and normal weight mice.
Abigail Usiyevich, Yufan Li, Reema Sharma, Kenny Arbuckle, Jay Shah, Bridget A. Matikainen-Ankney   +5 more
doaj   +1 more source

Urban Dark Sky Environmental Evolution Identification and Associated Explanatory Factors Analysis for Dark Sky Park Development

Land
The expansion of artificial nighttime lighting has increased the risk of urban dark sky environmental degradation. Identifying long-term evolution patterns and their associated socioeconomic and environmental factors is essential for conserving dark sky ...
Yeping Zhang, Ruili Guo, Zhibo Xu
doaj   +1 more source