Results 71 to 80 of about 22,035 (254)

A novel ultra performance liquid chromatography-PDA method development and validation for darunavir in bulk and its application to marketed dosage form

Journal of Pharmacy and Bioallied Sciences, 2021
Aims and Objective: The aim of this study was to develop and validate a novel ultra-performance liquid chromatographic method for estimation of darunavir in a bulk and tablet dosage form. Materials and Methods: The chromatographic separation was achieved
Sabyasachi Biswal, Sumanta Mondal, Prasenjit Mondal   +2 more
doaj   +1 more source

Improvement of neuropsychological performances and reduction of immune-activation markers after probiotic supplementation and change of life-style in an HIV positive male: targeting the microbiota to act on gut-brain axis [PDF]

, 2017
The gut-brain axis is widely in uenced by the intestinal microbiota and dysbiosis is consequently associated with a large dysregulation of its functions. Probiotic supplementation, reducing the harmful effects of dysbiosis, has shown positive effects not
Bianchi, Luigi, Cavallari, EUGENIO NELSON, Ceccarelli, Giancarlo, Corano Scheri, Giuseppe, D'Ettorre, Gabriella, Gabriella Di Girolamo,, Martiangela, Fratino, Vassalini, Paolo, Vullo, Vincenzo   +8 more
core  

Virological outcomes with Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in people previously treated with darunavir‐based antiretroviral therapy

HIV Medicine, EarlyView.
Abstract Background Darunavir‐based antiretroviral therapy (ART) is commonly used in people with HIV who experience adherence challenges and/or have complex resistance patterns. Changes in ART commissioning have led to an increased use of Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in these populations despite limited real‐world outcome ...
Rhianna Sheridan, Yasmin Osei‐Kuffour Ekert, Lucy Campbell, Mark Zuckerman, Sally Hawkins, Kate Childs, Frank A. Post   +6 more
wiley   +1 more source

Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals [PDF]

, 2017
Objectives Darunavir is a protease inhibitor that is administered with low-dose ritonavir to enhance its bioavailability. It is prescribed at standard dosage regimens of 600/100 mg twice daily in treatment-experienced patients and 800/100 mg once daily ...
Aouri, M., Arab-Alameddine, M., Battegay, M., Bernasconi, E., Bucher, H. C., Buclin, T., Böni, J., Bürgisser, P., Calmy, A., Cattacin, S., Cavassini, M., Cavassini, M., Csajka, C., de Tejada, B. M., Dubs, R., Décosterd, L. A., Egger, M., Elzi, L., Fayet-Mello, A., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Furrer, H., Fux, C. A., Gatri, M., Gorgievski, M., Guidi, M., Günthard, H., Hirsch, H. H., Hirschel, B., Hösli, I., Kahlert, C., Kaiser, L., Karrer, U., Kind, C., Klimkait, T., Ledergerber, B., Ledergerber, B., Lubomirov, R., Martinetti, G., Müller, N., Nadal, D., Paccaud, F., Panchaud, A., Pantaleo, G., Rauch, A., Regenass, S., Rentsch, K., Rickenbach, M., Rotger, M., Rudin, C., Schmid, P., Schultze, D., Schüpbach, J., Speck, R., Taffé, P., Telenti, A., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Widmer, N., Yerly, S.   +63 more
core  

Monotherapy with boosted protease inhibitors as antiretroviral treatment simplification strategy in the clinical setting [PDF]

, 2012
Antiretroviral treatment simplification with darunavir/ritonavir or lopinavir/ritonavir monotherapy maintains sustained HIV viremia suppression in clinical trials.
B Clotet, C Miranda, D Berrio, I Bravo, J Llibre, J Moltó, J Santos, R Paredes, S Pé   +8 more
core   +1 more source

Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6

Clinical Pharmacokinetics, 2020
Darunavir is an anti-HIV protease inhibitor repurposed for SARS-CoV-2 treatment. The aim of this study was to assess the population pharmacokinetics of darunavir in SARS-CoV-2 patients compared with HIV patients. Two separate models were created by means
P. Cojutti, A. Londero, P. Della Siega, Filippo Givone, M. Fabris, Jessica Biasizzo, C. Tascini, F. Pea   +7 more
semanticscholar   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Combating HIV resistance – focus on darunavir

Therapeutics and Clinical Risk Management, 2008
Cécile L Tremblay11Department of Microbiology and Immunology, Centre Hospitalier de l’Université de Montréal, Montréal, CanadaAbstract: Darunavir is a second-generation protease inhibitor designed to ...
Cécile L Tremblay
doaj  

Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV Type 1-infected subjects over 48 weeks [PDF]

, 2012
We assessed metabolic changes for darunavir/ritonavir (DRV/r) once daily (qd) versus atazanavir/ritonavir (ATV/r) qd with fixed-dose tenofovir/emtricitabine. This was a phase 4, multicenter, open-label, randomized exploratory study.
Aberg, Judith A, De La Rosa, Guy, Falcon, Ron, Gupta, Samir K, Landay, Alan, Overton, Edgar Turner, Ryan, Robert, Sax, Paul E, Tebas, Pablo   +8 more
core   +2 more sources

Automated Near Real‐Time QC for LC‐HRMS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 10, 30 May 2026.
ABSTRACT Rationale The quality of analytical measurements is typically evaluated after completion of the entire, or possibly multiple, measurement batch(es). Automated, near real‐time quality control (QC) during LC‐HRMS acquisition can prevent reruns and sample loss by flagging issues as they occur.
Michael J. Mohr, Linus Strähle, Tobias Bader, Pia Leurle, Jan H. Christensen, Wolfram Seitz, Rudi Winzenbacher   +6 more
wiley   +1 more source