Results 41 to 50 of about 3,265 (196)

Evidencia de asociación entre el genotipo 10/10 de DAT1 y endofenotipos del trastorno por déficit de atención/hiperactividad

Neurología, 2015
Resumen: Introducción: La variancia genética del trastorno por déficit de atención e hiperactividad (TDAH) es determinante para el fenotipo. La repetición en tándem en número variable (VNTR) de 40 pares de bases (pb) en la región no traducida 3’ (UTR ...
J.A. Agudelo, J.M. Gálvez, D.J. Fonseca, H.E. Mateus, C. Talero-Gutiérrez, A. Velez-Van-Meerbeke   +5 more
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Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency

Brain Sciences, 2020
The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, as well as epigenetic factors. Many studies have attempted to discover a molecular basis for this disease.
Anna Grzywacz, Wojciech Barczak, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Suchanecka, Grzegorz Trybek, Jolanta Masiak, Paweł Jagielski, Katarzyna Grocholewicz, Blazej Rubiś   +9 more
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DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics

Pharmacogenomics and Personalized Medicine, 2010
Attention deficit/hyperactivity disorder (ADHD) is a common and potentially very impairing neuropsychiatric disorder of childhood. Statistical genetic studies of twins have shown ADHD to be highly heritable, with the combination of genes and gene by environment interactions accounting for around 80% of phenotypic variance. The initial molecular genetic
Turic, D., Swanson, J., Sonuga-Barke, Edmund J.S.   +2 more
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Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1) [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractIn this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double‐blind conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine ...
Kooij, J.S., Boonstra, A.M., Vermeulen, H.H.M., Heister, J.G.A.M., Burger, H., Buitelaar, J.K., Buitelaar, J.K., Franke, B., Franke, B.   +8 more
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Localization of the dopamine transporter gene, Dat1, on mouse Chromosome 13 [PDF]

Mammalian Genome, 1994
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/47009/1/335_2004_Article_BF00292340 ...
Vandenbergh, D. J., Lossie, Amy C., Camper, Sally A., Uhl, G. R.   +3 more
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G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation

Biochemistry and Biophysics Reports, 2023
The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain, Anju Singh, Shoaib Khan, Shrikant Kukreti   +3 more
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DNA binding properties of theSaccharomyces cerevisiae DAT1gene product [PDF]

Nucleic Acids Research, 1995
The DAT1 gene of Saccharomyces cerevisiae encodes a DNA binding protein (Dat1p) that specifically recognizes the minor groove of non-alternating oligo(A).oligo(T) tracts. Sequence-specific recognition requires arginine residues found within three perfectly repeated pentads (G-R-K-P-G) of the Dat1p DNA binding domain [Reardon, B. J., Winters, R.
B J, Reardon, D, Gordon, M J, Ballard, E, Winter   +3 more
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Interactive Regulation of Formate Dehydrogenase during CO₂ Fixation in Gas-Fermenting Bacteria

mBio, 2020
Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely ...
Lu Zhang, Yanqiang Liu, Ran Zhao, Can Zhang, Weihong Jiang, Yang Gu   +5 more
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Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

Scientific Reports, 2021
The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of ...
Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn   +13 more
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The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders

Brain Sciences, 2021
Schizophrenia spectrum disorders (SZ) are characterized by impairments in probabilistic reinforcement learning (RL), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia.
Dorota Frydecka, Błażej Misiak, Patryk Piotrowski, Tomasz Bielawski, Edyta Pawlak, Ewa Kłosińska, Maja Krefft, Kamila Al Noaimy, Joanna Rymaszewska, Ahmed A. Moustafa, Jarosław Drapała   +10 more
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