Results 41 to 50 of about 8,689 (241)

DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics

Pharmacogenomics and Personalized Medicine, 2010
Attention deficit/hyperactivity disorder (ADHD) is a common and potentially very impairing neuropsychiatric disorder of childhood. Statistical genetic studies of twins have shown ADHD to be highly heritable, with the combination of genes and gene by environment interactions accounting for around 80% of phenotypic variance. The initial molecular genetic
Turic, D., Swanson, J., Sonuga-Barke, Edmund J.S.   +2 more
openaire   +4 more sources

The role of DAT1 gene on the rapid detection of task novelty

Neuropsychologia, 2010
In an environment with a myriad of different stimuli, the fast detection of novel and behaviorally relevant signals becomes crucial for an adaptive behavior. The detection of task-novelty has been related to striatum-prefrontal cortex (PFC) pathways involving dopaminergic (DA) neurotransmission.
Garcia-Garcia M, Barceló F, Clemente I, Escera C   +3 more
openaire   +4 more sources

Association between 5HTT, DAT1, and DRD4 and bipolar disorder in youth [PDF]

Psychiatric Genetics, 2012
Bipolar disorder (BD) in youth is characterized by rapid fluctuation between high and low mood states, severe irritability, and multiple psychiatric comorbidities. Left untreated, affected youth may demonstrate compromised development in social, neurobiological, cognitive, and emotional realms (Miklowitz & Cicchetti 2006).
Cosgrove, V, Miklowitz, D, Rhee, S, Hawkey, C, Corley, R, Haberstick, B, Smolen, A   +6 more
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Evidencia de asociación entre el genotipo 10/10 de DAT1 y endofenotipos del trastorno por déficit de atención/hiperactividad

Neurología, 2015
Resumen: Introducción: La variancia genética del trastorno por déficit de atención e hiperactividad (TDAH) es determinante para el fenotipo. La repetición en tándem en número variable (VNTR) de 40 pares de bases (pb) en la región no traducida 3’ (UTR ...
J.A. Agudelo, J.M. Gálvez, D.J. Fonseca, H.E. Mateus, C. Talero-Gutiérrez, A. Velez-Van-Meerbeke   +5 more
doaj   +1 more source

Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency

Brain Sciences, 2020
The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, as well as epigenetic factors. Many studies have attempted to discover a molecular basis for this disease.
Anna Grzywacz, Wojciech Barczak, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Suchanecka, Grzegorz Trybek, Jolanta Masiak, Paweł Jagielski, Katarzyna Grocholewicz, Blazej Rubiś   +9 more
doaj   +1 more source

Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1) [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractIn this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double‐blind conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine ...
Kooij, J.S., Boonstra, A.M., Vermeulen, H.H.M., Heister, J.G.A.M., Burger, H., Buitelaar, J.K., Buitelaar, J.K., Franke, B., Franke, B.   +8 more
openaire   +4 more sources

G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation

Biochemistry and Biophysics Reports, 2023
The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain, Anju Singh, Shoaib Khan, Shrikant Kukreti   +3 more
doaj   +1 more source

Dopamine transporter and transmission of psychopathological risk. A review of gene-environment interplay [PDF]

, 2017
Research underlines that intergenerational transmission of psychopathological risk results from a complex interplay of genetic and environmental risk factors which predispose child to develop emotionalbehavioral problems. Mechanisms of transmission are
Ballarotto, Giulia, Cerniglia, Luca, Cimino, Silvia, Marzilli, Eleonora, Pascale, Esterina, Walter, Adriani   +5 more
core   +1 more source

Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing. [PDF]

PLoS ONE, 2011
Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing--the error-related negativity (ERN) and the ...
Stefanie C Biehl, Thomas Dresler, Andreas Reif, Peter Scheuerpflug, Jürgen Deckert, Martin J Herrmann   +5 more
doaj   +1 more source

The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults [PDF]

, 2016
There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism.
Billino, Jutta, Gegenfurtner, Karl R., Hennig, Jürgen   +2 more
core   +1 more source