Results 41 to 50 of about 3,746 (200)

G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation

Biochemistry and Biophysics Reports, 2023
The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain, Anju Singh, Shoaib Khan, Shrikant Kukreti   +3 more
doaj   +1 more source

Localization of the dopamine transporter gene, Dat1, on mouse Chromosome 13 [PDF]

Mammalian Genome, 1994
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/47009/1/335_2004_Article_BF00292340 ...
Vandenbergh, D. J., Lossie, Amy C., Camper, Sally A., Uhl, G. R.   +3 more
openaire   +3 more sources

Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing. [PDF]

PLoS ONE, 2011
Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing--the error-related negativity (ERN) and the ...
Stefanie C Biehl, Thomas Dresler, Andreas Reif, Peter Scheuerpflug, Jürgen Deckert, Martin J Herrmann   +5 more
doaj   +1 more source

3207 Relation between Dopamine Transporter (DAT1) polymorphism and subjective effects of alcohol among non-dependent drinkers

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Dopamine transporter (DAT1) gene variation is associated with reward-related phenotypes including alcohol response. There is also evidence for a potential moderating role for mu-opioid receptor (OPRM1) gene variation on the ...
Soundarya Soundararajan, Bethany L. Stangl, Courtney L. Vaughan, Hui Sun, Falk Lohoff, Melanie L. Schwandt, Vijay Ramchandani   +6 more
doaj   +1 more source

Interactive Regulation of Formate Dehydrogenase during CO₂ Fixation in Gas-Fermenting Bacteria

mBio, 2020
Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely ...
Lu Zhang, Yanqiang Liu, Ran Zhao, Can Zhang, Weihong Jiang, Yang Gu   +5 more
doaj   +1 more source

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

Scientific Reports, 2021
The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of ...
Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn   +13 more
doaj   +1 more source

The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders

Brain Sciences, 2021
Schizophrenia spectrum disorders (SZ) are characterized by impairments in probabilistic reinforcement learning (RL), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia.
Dorota Frydecka, Błażej Misiak, Patryk Piotrowski, Tomasz Bielawski, Edyta Pawlak, Ewa Kłosińska, Maja Krefft, Kamila Al Noaimy, Joanna Rymaszewska, Ahmed A. Moustafa, Jarosław Drapała   +10 more
doaj   +1 more source

Methylation of the DAT1 dopamine transporter gene in combat sport athletes: Associations with impulsivity and reward sensitivity

Baltic Journal of Health and Physical Activity
Epigenetic mechanisms, such as DNA methylation, modulate behavioral traits, including impulsivity and reward sensitivity. The dopamine transporter gene (DAT1) plays a key role in dopaminergic function and is associated with self-regulation, attention ...
Milena Lachowicz, Remigiusz Recław, Aleksandra SUCHANECKA, Krzysztof Chmielowiec, Elżbieta Grzywacz, Jolanta Chmielowiec, Kinga Łosińska, Anna Grzywacz   +7 more
doaj   +1 more source

Externalizing Problem Behavior in Adolescence: Parenting Interacting With DAT1 and DRD4 Genes [PDF]

Journal of Research on Adolescence, 2016
This study extends previous gene‐by‐environment (G × E) research through design and methodological advances and examines alternative hypotheses of diathesis stress, vantage sensitivity, and differential susceptibility. In a sample of 984 adolescents and their parents, we examined whether effects of parental support, proactive, punitive, harsh punitive,
Janssens, Annelies, Van Den Noortgate, Wim, Goossens, Luc, Colpin, Hilde, Verschueren, Karine, Claes, Stephan, Van Leeuwen, Karla   +6 more
openaire   +3 more sources

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

BMC Psychiatry, 2009
Background Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD.
Huang Yu-Shu, Chen Chih-Ken, Sun Bo, Mill Jonathan, Xu Xiaohui, Wu Yu-Yu, Asherson Philip   +6 more
doaj   +1 more source