There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood.
F. Nemmi +17 more
doaj +2 more sources
Interactive Effects of OPRM1 and DAT1 Genetic Variation on Subjective Responses to Alcohol [PDF]
Subjective response to alcohol represents a marker of alcoholism risk. The A118G single-nucleotide polymorphism (SNP) of the mu opioid receptor (OPRM1) gene has been associated with subjective response to alcohol. Recently, the dopamine transporter (DAT1) variable number of tandem repeat (VNTR; SLC6A3) has been found to interact with the OPRM1 A118G ...
Lara A. Ray +4 more
openalex +6 more sources
Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits. [PDF]
This graphical abstract illustrates the relationship between DAT1 gene methylation, personality traits, and cannabis use disorder (CUD). In a sample of 490 study group (212 with CUD and 278 controls), methylation at 33 CpG sites within the DAT1 promoter region was assessed alongside personality traits using the NEO‐FFI and STAI.
Suchanecka A +5 more
europepmc +2 more sources
Risk factors for avoidant/restrictive food intake disorder in children: A systematic review. [PDF]
Abstract Objectives Avoidant/restrictive food intake disorder (ARFID) is a relatively new diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM)‐5, since 2013. The restrictive and/or selective eating—driven by a lack of interest, sensory sensitivity, and/or concern over aversive consequences—is associated with significant medical ...
Nowacki R +4 more
europepmc +2 more sources
Influence of DAT1 Promotor Methylation on Sports Performance [PDF]
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factors (TFs) to DNA.
Anna Grzywacz +9 more
openaire +2 more sources
Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (
Background The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been associated with a range of psychiatric phenotypes, most notably attention-deficit ...
D'Souza Ursula M +3 more
doaj +4 more sources
SLC6A3 (DAT1) as a Novel Candidate Biomarker Gene for Suicidal Behavior [PDF]
It has been previously shown that the serotonin and dopamine neurotransmitter systems might influence the predisposition to suicidal behavior. This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT, and BDNF to suicidal behavior and severity of symptoms of ...
Ekaterina Rafikova +6 more
openaire +2 more sources
Aggression and polymorphisms in AR, DAT1, DRD2 and COMT genes in Datoga pastoralists of Tanzania [PDF]
The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression.
Marina Butovskaya +9 more
openalex +3 more sources
Antipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia.
E. E. Vaiman +3 more
doaj +1 more source
Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice. [PDF]
BACKGROUND: It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly ...
Natalia P Bondar +4 more
doaj +1 more source

