Results 21 to 30 of about 3,265 (196)

DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004
AbstractRecent meta‐analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention‐deficit hyperactivity disorder (ADHD), although single studies frequently failed to show significant association.
Bakker, S.C., van der Meulen, E.M., Oteman, N, Schelleman, H., Pearson, P.L., Buitelaar, J.K., Sinke, R.J.   +6 more
openaire   +8 more sources

ADHD and DAT1: Further evidence of paternal over‐transmission of risk alleles and haplotype [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009
AbstractWe [Hawi et al. (2005); Am J Hum Genet 77:958–965] reported paternal over‐transmission of risk alleles in some ADHD‐associated genes. This was particularly clear in the case of the DAT1 3′‐UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over‐transmission of ...
Hawi, Z., Kent, L., Hill, M., Anney, R.J., Brookes, K.J., Barry, E., Franke, B., Franke, B., Banaschewski, T., Buitelaar, J.K., Ebstein, R., Miranda, A., Oades, R.D., Roeyers, H., Rothenberger, A., Sergeant, J.A., Sonuga-Barke, E.J.S., Steinhausen, H.C., Faraone, S.V., Asherson, P., Gill, M.   +20 more
openaire   +10 more sources

VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome [PDF]

Frontiers in Behavioral Neuroscience, 2016
Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to ...
Laura Del Hoyo, Laura Del Hoyo, Laura Xicota, Laura Xicota, Laura Xicota, Klaus Langohr, Klaus Langohr, Gonzalo Sánchez-Benavides, Susana De Sola, Susana De Sola, Aida M Cuenca-Royo, Joan Rodriguez, Josep Rodriguez, Magi Farre, Mara Dierssen, Mara Dierssen, Mara Dierssen, Rafael De La Torre, Rafael De La Torre, Rafael De La Torre   +19 more
doaj   +2 more sources

Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population

Neuropsychiatric Disease and Treatment, 2017
 Maciej Bieliński,1 Marcin Jaracz,1 Natalia Lesiewska,1 Marta Tomaszewska,1 Marcin Sikora,2 Roman Junik,3 Anna Kamińska,3 Andrzej Tretyn,2 Alina Borkowska1 1Department of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium ...
Bieliński M, Jaracz M, Lesiewska N, Tomaszewska M, Sikora M, Junik R, Kamińska A, Tretyn A, Borkowska A   +8 more
doaj   +1 more source

Testing DAT1 and DRD4 Genes in Attention Deficit Hyperactivity Disorder Using a Wide Spectrum of Neurocognitive Batteries. [PDF]

Int J Dev Neurosci
This study examined DAT1 and DRD4 VNTR polymorphisms and neurocognitive performance in 336 children and adolescents with ADHD and controls using the CNS Vital Signs battery. DAT1 10R/10R showed no significant effects after adjustment, whereas DRD4 4R/4R was associated with reduced cognitive flexibility. ABSTRACT Attention‐deficit/hyperactivity disorder
Ünsel-Bolat G, Bolat H, Yıldırım S, Özgül S, Tahıllıoğlu A, Yazıcı KU, Bacanlı A, Parıltay E, Aygüneş-Jafari D, Kosova B, Rohde LA, Akın H, Ercan ES.   +12 more
europepmc   +2 more sources

Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1) [PDF]

BMC Genetics, 2005
Background The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been associated with a range of psychiatric phenotypes, most notably attention-deficit ...
D'Souza Ursula M, Craig Ian, Asherson Philip, Mill Jonathan   +3 more
doaj   +4 more sources

Risk factors for avoidant/restrictive food intake disorder in children: A systematic review. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives Avoidant/restrictive food intake disorder (ARFID) is a relatively new diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM)‐5, since 2013. The restrictive and/or selective eating—driven by a lack of interest, sensory sensitivity, and/or concern over aversive consequences—is associated with significant medical ...
Nowacki R, Arayess L, Kleijnen J, Vreugdenhil A, Mulkens S.   +4 more
europepmc   +2 more sources

Influence of DAT1 Promotor Methylation on Sports Performance [PDF]

Genes, 2021
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factors (TFs) to DNA.
Anna Grzywacz, Krzysztof Chmielowiec, Agnieszka Boroń, Monika Michałowska-Sawczyn, Jolanta Chmielowiec, Grzegorz Trybek, Bożena Mroczek, Katarzyna Leźnicka, Paweł Cieszczyk, Jolanta Masiak   +9 more
openaire   +2 more sources

Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits. [PDF]

Genes Brain Behav
This graphical abstract illustrates the relationship between DAT1 gene methylation, personality traits, and cannabis use disorder (CUD). In a sample of 490 study group (212 with CUD and 278 controls), methylation at 33 CpG sites within the DAT1 promoter region was assessed alongside personality traits using the NEO‐FFI and STAI.
Suchanecka A, Recław R, Chmielowiec K, Chmielowiec J, Masiak J, Grzywacz A.   +5 more
europepmc   +2 more sources

The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review. [PDF]

J Exp Anal Behav
Abstract Dr. Warren Bickel tirelessly investigated delay discounting (DD), a behavioral economic index of impulsive decision making, as a determinant of numerous health outcomes. Among the factors that contribute to a person's level of DD, a burgeoning body of research has illuminated its genetic foundations and the extent to which it may be a ...
Deng WQ, Belisario KL, Doggett A, Elsayed M, Cooper A, MacKillop J.   +5 more
europepmc   +2 more sources