Results 1 to 10 of about 3,265 (196)

Interaction Between the VNTR of the DAT1 Gene and DAT1 Methylation in Relation to Impulsivity in Combat Sports Athletes [PDF]

Biomedicines
Background: Dopaminergic signaling is a key mechanism in behavioral regulation and impulse control. While DAT1 promoter methylation has been linked to behavioral dysregulation in clinical groups, its role in high-functioning populations such as elite ...
Remigiusz Recław, Jolanta Chmielowiec, Krzysztof Chmielowiec, Dariusz Larysz, Agnieszka Pedrycz, Anna Grzywacz   +5 more
doaj   +4 more sources

Associations Between DAT1 Gene VNTR Polymorphism and Impulsivity Dimensions in Individuals with Behavioural Addictions [PDF]

Biomedicines
Background/Objectives: Impulsivity is a key psychological construct implicated in the onset and maintenance of behavioural addictions. Dysregulation of impulsivity is central to behavioural addictions, yet its genetic basis remains unclear.
Remigiusz Recław, Aleksandra Suchanecka, Elżbieta Grzywacz, Krzysztof Chmielowiec, Jolanta Chmielowiec, Anna Makarewicz, Kinga Łosińska, Dariusz Larysz, Grzegorz Trybek, Anna Grzywacz   +9 more
doaj   +3 more sources

The functional minisatellite at the 3’-UTR of SLC6A3/DAT1 and dementia spectrum disorders: an association study in a population of Central Italy [PDF]

BMC Medical Genomics
Background Dementia comprises a spectrum of neurodegenerative disorders marked by progressive cognitive and behavioural decline, with Alzheimer’s disease (AD) being the most prevalent form.
Benedetta Torbidoni-Baldassari, Anna Giulia Guazzarini, Gabriele Rezza, Patrizia Bastiani, Roberta Cecchetti, Patrizia Mecocci, Valerio Napolioni   +6 more
doaj   +2 more sources

Mild internet use is associated with epigenetic alterations of key neurotransmission genes in salivary DNA of young university students [PDF]

Scientific Reports, 2023
The potentially problematic use of the Internet is a growing concern worldwide, which causes and consequences are not completely understood yet. The neurobiology of Internet addiction (IA) has attracted much attention in scientific research, which is now
Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell’Osso, Claudio D’Addario   +10 more
doaj   +2 more sources

Dopaminergic gene–epigenetic interactions and impulsivity traits in elite combat sport athletes [PDF]

Frontiers in Psychology
Dopaminergic signaling is a key mechanism underlying behavioral regulation and impulse control. While epigenetic variation in dopaminergic genes has been linked to dysregulated behavior in clinical populations, its relevance in high-functioning ...
Remigiusz Recław, Remigiusz Recław, Jolanta Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Anna Grzywacz, Anna Grzywacz   +6 more
doaj   +2 more sources

Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics [PDF]

Biomedicines
Background: Coping with stress is essential for mental well-being and can be critical for highly sensitive individuals, characterized by a deeper perception and processing of stimuli.
Fabio Bellia, Alessandro Piccinini, Eugenia Annunzi, Loreta Cannito, Francesca Lionetti, Bernardo Dell’Osso, Walter Adriani, Enrico Dainese, Alberto Di Domenico, Mariangela Pucci, Riccardo Palumbo, Claudio D’Addario   +11 more
doaj   +2 more sources

Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2006
AbstractA polymorphism in the dopamine transporter gene (DAT1) has been previously associated with ADHD and methylphenidate has been hypothesized to block the dopamine transporter. The goal of this study was to examine whether a 40‐bp variable number of tandem repeats (VNTR) of DAT1 moderate response and adverse effects associated with methylphenidate ...
Eric Mick, Joseph Biederman, Stephen V Faraone   +2 more
exaly   +3 more sources

Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains [PDF]

Behavioral and Brain Functions, 2005
Background The Spontaneously Hypertensive Rat (SHR) shows a number of behaviours that closely parallel those seen in children with attention-deficit hyperactivity disorder.
Mill Jonathan, Sagvolden Terje, Asherson Philip   +2 more
doaj   +5 more sources

DAT1 5′-Un-Translated-Region Methylation Patterns as Bio-Markers of ADHD Psycho-Pathology: Contribution to Disease Prognosis and to Monitoring of a Successful Therapy [PDF]

Biomedicines, 2023
Epigenetic modifications, such as changes in DNA methylation, have been linked to several diseases in recent years. The purpose of our study was to search for biomarkers that (using non-invasive techniques) could assist the clinician in the prognosis of ...
Valentina Carpentieri, Silvia Cugno, Katarina Lockic, Esterina Pascale, Walter Adriani   +4 more
doaj   +2 more sources

DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology. [PDF]

Neurobiol Aging
Previous work has associated polymorphisms in the dopamine transporter gene (rs6347 in DAT1/SLC6A3) and brain derived neurotrophic factor gene (Val66Met in BDNF) with atrophy and memory decline. However, it is unclear whether these polymorphisms relate to atrophy and cognition through associations with Alzheimer's disease pathology.
Ciampa CJ, Morin TM, Murphy A, Joie R, Landau SM, Berry AS, Alzheimer’s Disease Neuroimaging Initiative.   +6 more
europepmc   +3 more sources