Results 11 to 20 of about 8,689 (241)

Testing DAT1 and DRD4 Genes in Attention Deficit Hyperactivity Disorder Using a Wide Spectrum of Neurocognitive Batteries. [PDF]

Int J Dev Neurosci
This study examined DAT1 and DRD4 VNTR polymorphisms and neurocognitive performance in 336 children and adolescents with ADHD and controls using the CNS Vital Signs battery. DAT1 10R/10R showed no significant effects after adjustment, whereas DRD4 4R/4R was associated with reduced cognitive flexibility. ABSTRACT Attention‐deficit/hyperactivity disorder
Ünsel-Bolat G, Bolat H, Yıldırım S, Özgül S, Tahıllıoğlu A, Yazıcı KU, Bacanlı A, Parıltay E, Aygüneş-Jafari D, Kosova B, Rohde LA, Akın H, Ercan ES.   +12 more
europepmc   +3 more sources

A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in Alzheimer’s Disease [PDF]

Alzheimers Dement
Abstract Background Apathy in patients with Alzheimer’s disease (AD) is associated with significant morbidity. We examined whether interactions between genetic variants related to neurotransmitter systems and regional brain atrophy are associated with apathy in patients with mild cognitive impairment (MCI) and AD.
Malik R, Beaton D, Saykin A, Nho K, Finger E.   +4 more
europepmc   +4 more sources

Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics [PDF]

Biomedicines
Background: Coping with stress is essential for mental well-being and can be critical for highly sensitive individuals, characterized by a deeper perception and processing of stimuli.
Fabio Bellia, Alessandro Piccinini, Eugenia Annunzi, Loreta Cannito, Francesca Lionetti, Bernardo Dell’Osso, Walter Adriani, Enrico Dainese, Alberto Di Domenico, Mariangela Pucci, Riccardo Palumbo, Claudio D’Addario   +11 more
doaj   +2 more sources

Dopaminergic control of attentional flexibility: inhibition of return is associated with the dopamine transporter gene (DAT1)

Frontiers in Human Neuroscience, 2010
Genetic variability related to the dopamine (DA) transporter gene (DAT1) has received increasing attention as a possible modulator of human cognition. The 9-repeat allele of the DAT1 gene is presumably associated with higher striatal DA levels than the ...
Lorenza S Colzato, Jay Pratt, Bernhard Hommel   +2 more
doaj   +2 more sources

Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2006
AbstractA polymorphism in the dopamine transporter gene (DAT1) has been previously associated with ADHD and methylphenidate has been hypothesized to block the dopamine transporter. The goal of this study was to examine whether a 40‐bp variable number of tandem repeats (VNTR) of DAT1 moderate response and adverse effects associated with methylphenidate ...
Eric Mick, Joseph Biederman, Stephen V Faraone   +2 more
exaly   +5 more sources

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice [PDF]

, 2008
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been ...
Irina L. Kovalenko, Maxim L. Filipenko, Natalia N. Kudryavtseva, Natalia P. Bondar, Ul'   +4 more
core   +4 more sources

DAT1 5′-Un-Translated-Region Methylation Patterns as Bio-Markers of ADHD Psycho-Pathology: Contribution to Disease Prognosis and to Monitoring of a Successful Therapy [PDF]

Biomedicines, 2023
Epigenetic modifications, such as changes in DNA methylation, have been linked to several diseases in recent years. The purpose of our study was to search for biomarkers that (using non-invasive techniques) could assist the clinician in the prognosis of ...
Valentina Carpentieri, Silvia Cugno, Katarina Lockic, Esterina Pascale, Walter Adriani   +4 more
doaj   +2 more sources

The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task [PDF]

Brain Imaging and Behavior, 2016
Dopaminergic brain circuits participate in emotional processing and impulsivity. The dopamine transporter (DAT) modulates dopamine reuptake. A variable number tandem repeat (VNTR) in the dopamine transporter gene (DAT1) affects DAT expression.
Anand, Amit, Brown, Brenna K., Karne, Harish, Murrell, Jill   +3 more
core   +4 more sources

Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains [PDF]

Behavioral and Brain Functions, 2005
Background The Spontaneously Hypertensive Rat (SHR) shows a number of behaviours that closely parallel those seen in children with attention-deficit hyperactivity disorder.
Mill Jonathan, Sagvolden Terje, Asherson Philip   +2 more
doaj   +5 more sources

DRD4 and DAT1 Polymorphisms Modulate Human Gamma Band Responses [PDF]

Cerebral Cortex, 2006
Gamma oscillations (30-80 Hz) have been demonstrated to be important for perceptual and cognitive processes. Animal and in vitro studies have revealed possible underlying generation mechanisms of the gamma rhythm. However, little is known about the neurochemical modulation of these oscillations during human cognition.
Tamer Demıralp, Christoph S. Herrmann, Mehmet Emin Erdal, Tolgay Ergenoğlu, Yasemin H. Keskin, Mehmet Ergen, Hüseyin Beydağı   +6 more
openalex   +3 more sources