Results 31 to 40 of about 8,689 (241)

DAT1 and DRD4 genes involved in key dimensions of adult ADHD [PDF]

Neurological Sciences, 2015
Attention-deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder often persisting in adulthood. Genetic studies of ADHD mainly focused on the Dopamine Transporter (DAT1) and the Dopamine Receptor 4 (DRD4) genes. Nevertheless, polymorphisms of these genes explain only a small fraction of the assigned risk, suggesting ...
Hasler, Roland, Salzmann, Annick, Bolzan, Tiffany, Zimmermann, Julien, Baud, Patrick, Giannakopoulos, Panteleimon, Perroud, Nader Ali   +6 more
openaire   +4 more sources

Methylation in the Promoter Region of the Dopamine Transporter DAT1 Gene in People Addicted to Nicotine [PDF]

International Journal of Environmental Research and Public Health, 2022
The dopaminergic system is a crucial element of the addiction processes. The dopamine transporter modulates the dynamics and levels of released dopamine in the synaptic cleft. Therefore, regulation of dopamine transporter (DAT1) gene expression is critical for maintaining homeostasis in the dopaminergic system. The aim of our study is evaluation of the
Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Strońska-Pluta, Aleksandra Suchanecka, Kinga Humińska‐Lisowska, Milena Lachowicz, Marta Niewczas, Monika Białecka, Małgorzata Śmiarowska, Anna Grzywacz   +9 more
openalex   +3 more sources

Localization of the dopamine transporter gene, Dat1, on mouse Chromosome 13 [PDF]

Mammalian Genome, 1994
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/47009/1/335_2004_Article_BF00292340 ...
Amy C. Lossie, David J. Vandenbergh, George R. Uhl, Sally A. Camper   +3 more
openalex   +5 more sources

The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]

, 2006
Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Bernstein, HG, Bunzeck, N, Duzel, E, Fenker, DB, Gundelfinger, ED, Heinze, HJ, Lauer, CJ, Schott, BH, Seidenbecher, CI, Tischmeyer, W   +9 more
core   +1 more source

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

European Psychiatry, 2020
BackgroundThere is a growing number of studies showing interactions between genetic polymorphisms associated with dopaminergic neurotransmission and traumatic life events (TLEs) on a risk of psychotic-like experiences (PLEs).
Dorota Frydecka, Kamila Kotowicz, Łukasz Gawęda, Katarzyna Prochwicz, Joanna Kłosowska, Joanna Rymaszewska, Agnieszka Samochowiec, Jerzy Samochowiec, Piotr Podwalski, Edyta Pawlak-Adamska, Elżbieta Szmida, Andrzej Cechnicki, Błażej Misiak   +12 more
doaj   +1 more source

DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]

, 2018
Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario, Claudio D’Addario, Eleonora Marzilli, Esterina Pascale, Giulia Ballarotto, Luca Cerniglia, Renata Tambelli, Silvia Cimino, Walter Adriani, Walter Adriani   +9 more
core   +2 more sources

DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004
AbstractRecent meta‐analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention‐deficit hyperactivity disorder (ADHD), although single studies frequently failed to show significant association.
Bakker, S.C., van der Meulen, E.M., Oteman, N, Schelleman, H., Pearson, P.L., Buitelaar, J.K., Sinke, R.J.   +6 more
openaire   +7 more sources

The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density

BMC Genetics, 2005
Background A 40-bp variable number of tandem repeats (VNTR) polymorphism exists in the 15th exon of DAT1, the gene encoding the human dopamine transporter (DAT).
Kilts Clinton D, Owens Michael J, VanNess Sidney H   +2 more
doaj   +1 more source

From genes to behavior: placing cognitive models in the context of biological pathways. [PDF]

, 2014
Connecting neural mechanisms of behavior to their underlying molecular and genetic substrates has important scientific and clinical implications. However, despite rapid growth in our knowledge of the functions and computational properties of neural ...
Hsu, Ming, Saez, Ignacio, Set, Eric
core   +3 more sources

Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: A meta-analysis in four European populations [PDF]

, 2011
Attention-deficit hyperactivity disorder (ADHD) is a common behavioral disorder affecting about 4–8% of children. ADHD persists into adulthood in around 65% of cases, either as the full condition or in partial remission with persistence of symptoms ...
Asherson, P., Bayés, M., Bosch, R., Brunso, L., Buitelaar, J., Casas, M., Cormand, B., Faraone, S., Fernàndez-Castillo, N., Franke, B., Gross-Lesch, S., Haavik, J., Hoogman, M., Jacob, C., Jacobsen, K., Johansson, S., Kiemeney, L., Kooij, J., Kreiker, S., Landaas, E., Lesch, K., Lundervold, A., Mick, E., Ramos-Quiroga, J., Reif, A., Ribasés, M., Sánchez-Mora, C.   +26 more
core   +3 more sources