Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Data-Driven Economy and AI in Decision-Making Process: A Retail case study
reservedOver the past few decades, the world has undergone global changes that have affected all spheres of human activity, changed approaches to decision-making, increased the accuracy of predictions, and revealed patterns in the consequences of ...
ZIGANSHINA, ANASTASIIA
core
Insights into Target Gas-Oxygen Interactions in Highly Sensitive Gas Sensors Using Data-Driven Methods. [PDF]
ACS SensKim K +5 more
europepmc +1 more source
Data-Driven Methods for the Estimation of Leaf Water and Dry Matter Content: Performances, Potential and Limitations. [PDF]
Sensors (Basel), 2020 Yang B, Lin H, He Y.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
An algorithm for closed-loop data-driven simulation
Closed-loop data-driven simulation refers to the problem of constructing trajectories of a closed-loop system directly from data of the plant and a representation of the controller.
Markovsky, Ivan
core +1 more source
Improved food image recognition by leveraging deep learning and data-driven methods with an application to Central Asian Food Scene. [PDF]
Sci RepKarabay A, Varol HA, Chan MY.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Deep-Neural-Networks-Based Data-Driven Methods for Characterizing the Mechanical Behavior of Hydroxyl-Terminated Polyether Propellants. [PDF]
Polymers (Basel)Han R, Fu X, Qu B, Shi, Liu Y.
europepmc +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source