Results 191 to 200 of about 35,639,582 (304)

Initial production prediction for horizontal wells in tight sandstone gas reservoirs based on data-driven methods. [PDF]

Sci Rep
Sun J, Gao J, Tang K, Ren L, Zhang Y, Miao Z, Zhang Z.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Predictive Modeling of Acute Hypertensive Disorders in a Real-World Cohort: Integrating Clinical Predictors and Data-Driven Methods. [PDF]

Diagnostics (Basel)
Fucile I, Liccardi F, Manzi MV, Lembo M, Basile C, Santucci O, Auciello S, Maniscalco M, Spedicato GA, Morisco C, Izzo R, De Luca N, Ambrosino P, Mancusi C, Esposito G, Paladino F.   +15 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Genomic selection optimization in blueberry: Data-driven methods for marker and training population design. [PDF]

Plant Genome
Adunola P, Ferrão LFV, Benevenuto J, Azevedo CF, Munoz PR.   +4 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Quantification in respiratory-gated PET acquisition: can data-driven methods replace device-based systems?-a comparative and retrospective study. [PDF]

EJNMMI Res
Agrigoroaie L, Anizan N, Garcia C, Balleyguier C, Henry T.   +4 more
europepmc   +1 more source

Not There Yet: Using Data‐Driven Methods to Predict Who Becomes Costly Among Low‐Cost Patients with Type 2 Diabetes [PDF]

Health Serv Res, 2020
Lauffenburger J, Mahesri M, Choudhry N.
europepmc   +2 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Insights into Target Gas-Oxygen Interactions in Highly Sensitive Gas Sensors Using Data-Driven Methods. [PDF]

ACS Sens
Kim K, Pornaroontham P, Yun H, Kim S, Choi P, Masuda Y.   +5 more
europepmc   +1 more source