Results 91 to 100 of about 1,628,849 (334)

Digital curation after digital extraction for data sharing

open access: yesIASSIST Quarterly, 2018
Welcome to the third issue of volume 42 of the IASSIST Quarterly (IQ 42:3, 2018). The IASSIST Quarterly presents in this issue three papers from geographically widespread countries.
Karsten Boye Rasmussen
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

A competency framework for digital curation and data science [PDF]

open access: yes, 2013
"Aligning Digital Preservation across Nations" was a full-day invitational workshop held in conjunction with the International Digital Curation Conference (IDCC) 2013 in Amsterdam on 14 January 2013.
Corrall, Sheila, Corrall, Sheila
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Planning Data Management Education Initiatives: Process, Feedback, and Future Directions

open access: yesJournal of eScience Librarianship, 2014
Educating researchers in sound data management skills is a hot topic in today’s data intensive research world. Librarians across the country and the world are taking the lead in offering this training to their campus research communities.
Christopher Eaker
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Use of computer forensics in the digital curation of removable media [PDF]

open access: yes, 2009
The purpose of this paper is to encourage the discussion of the potential place and value of digital forensics techniques when dealing with acquisitions on removable media in the field of digital curation.
Glisson, W.B.
core  

Understanding the value of curation: A survey of US data repository curation practices and perceptions.

open access: yesPLoS ONE
Data curators play an important role in assessing data quality and take actions that may ultimately lead to better, more valuable data products. This study explores the curation practices of data curators working within US-based data repositories.
Lisa R Johnston   +8 more
doaj   +1 more source

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