SCOPe: Structural Classification of Proteins--extended, integrating SCOP and ASTRAL data and classification of new structures. [PDF]
, 2013 Structural Classification of Proteins-extended (SCOPe, http://scop.berkeley.edu) is a database of protein structural relationships that extends the SCOP database.
Brenner, Steven E +2 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Design and Operation of The Keck Observatory Archive [PDF]
, 2014 The Infrared Processing and Analysis Center (IPAC) and the W. M. Keck Observatory (WMKO) operate an archive for the Keck Observatory. At the end of 2013, KOA completed the ingestion of data from all eight active observatory instruments. KOA will continue
Berriman, G. Bruce +8 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Data Curation oder (Retro) Digitalisierung ist mehr als die Produktion von Daten
o-bib. Das offene Bibliotheksjournal, 2015 Nahezu jede Bibliothek, die über Altbestand verfügt, beschäftigt sich heute mit dem Thema Digitalisierung. Dabei wird oftmals übersehen, dass die dauerhafte und möglichst nutzerfreundliche Bereitstellung (und letztlich die Archivierung) der erzeugten ...
Klaus Kempf
doaj +1 more source
The Data Curation Network: Leveraging Expertise to Curate Data at Scale
, 2019 The Data Curation Network launched the three-year pilot of a distributed model for the curation of research data in 2018. Good curation increases the value and impact of research data. The collaborative, networked approach of the Data Curation Network leverages the expertise across network members to enhance the local repository’s ability to curate ...
Blake, Mara, Herndon, Joel
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Data Curation and Preservation [PDF]
, 2020 Data is a valuable resource. In some scientific disciplines, experiments can be redone to reproduce the data. In environmental sciences, the observations and measurements of the earth and its surroundings commonly can be made only once: each time point records uniquely the state of the many earth processes.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Supporting emerging researchers in data management and curation [PDF]
, 2013 While scholarly publishing remains the key means for determining researchers’ impact, international funding body requirements and government recommendations relating to research data management (RDM), sharing and preservation mean that the underlying ...
Davidson, Joy
core