Results 101 to 110 of about 24,536,364 (296)

Measuring Governance Using Cross-Country Perceptions Data [PDF]

This paper describes an ongoing project to measure governance using crosscountry perceptions data. The governance indicators measure six dimensions of governance and cover 209 countries and territories for 1996-2004.
Kraay, Aart, Mastruzzi, Massimo, Kaufmann, Daniel   +2 more
core  

Sustainability: Politics and governance [PDF]

, 2016
he article gives an overview of global sustainability policy and politics. It is shown how international policy making on sustainable development has progressed from environmental policy toward recent approaches of Earth system governance. Key challenges
Global Sustainability Governance, Heinrichs, Harald, Martens, P., Environmental Governance, Heinrichs, H., Biermann, Frank, Michelsen, G., Wiek, A.   +7 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Aquaculture Ponds Identification Based on Multi-Feature Combination Strategy and Machine Learning from Landsat-5/8 in a Typical Inland Lake of China

Remote Sensing
Inland aquaculture ponds, as an important land use type, have brought great economic benefits to local people but at the same time have caused many environmental problems threatening regional ecology security.
Gang Xie, Xiaohui Bai, Yanbo Peng, Yi Li, Chuanxing Zhang, Yang Liu, Jinhui Liang, Lei Fang, Jinyue Chen, Jilin Men, Xinfeng Wang, Guoqiang Wang, Qiao Wang, Shilong Ren   +13 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Construction and Application Exploration of Data Foundations for Domain Large Models

Zhishi guanli luntan
[Purpose/Significance] In response to the practical demand for high-quality data support and trustworthy operation of domain large models in specialized and high-risk application scenarios, this study systematically examines the basic connotation, key ...
Xie Wenjun, Dong Huanqing, Cao Gaohui
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spectral–Spatial Hypergraph Convolutional Network for Hyperspectral Image Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In recent years, due to the high-order nonlinear modeling capability of hypergraph convolutional network (HGCN), it has been introduced into the field of hyperspectral image (HSI) classification.
Qingwang Wang, Fenlian Liu, Mingguo Wang, Lizhi Wang, Jiangbo Huang, Tao Shen   +5 more
doaj   +1 more source