Results 81 to 90 of about 28,117,703 (382)

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

“… so what?” Attitudes of the voluntary sector towards child protection in sports clubs [PDF]

, 2002
There is both growing concern about ethical standards in sport and also rapid expansion in the number of local and national schemes designed to encourage youth sports development.
Brackenridge, CH
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The promotion of data sharing in pharmacoepidemiology [PDF]

, 2014
This article addresses the role of pharmacoepidemiology in patient safety and the crucial role of data sharing in ensuring that such activities occur. Against the backdrop of proposed reforms of European data protection legislation, it considers whether ...
Sethi, Nayha
core   +1 more source

COVID-19 contact tracing apps: a stress test for privacy, the GDPR, and data protection regimes

Journal of Law and the Biosciences, 2020
Digital surveillance has played a key role in containing the COVID-19 outbreak in China, Singapore, Israel, and South Korea. Google and Apple recently announced the intention to build interfaces to allow Bluetooth contact tracking using Android and ...
L. Bradford, M. Aboy, K. Liddell
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Deep learning accelerated the discovery of multi‐principal element alloys with various strength‐toughness trade‐offs

Materials Genome Engineering Advances
Machine learning has significantly enhanced the efficiency of multi‐principal element alloys (MPEAs) development. Nonetheless, despite its potential, the rapid discovery of MPEAs with various strength‐toughness trade‐offs remains a largely unexplored ...
Chunhui Fan, Hong Luo, Qiancheng Zhao, Xuefei Wang, Hongxu Cheng, Yue Chang   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Rapid screening of the stability of polyacrylamide-based hydrogel coatings via droplet microarray analysis and interpretable machine learning

npj Materials Degradation
The unsatisfactory stability of hydrogel coatings hinders their functional and service performance. Until now, the development of high-performance hydrogel coatings largely relies on the intuition and prior experience of researchers. Machine learning, as
Jingzhi Yang, Yami Ran, Yuting Jin, Annan Kong, Mingyue Zhang, Lingwei Ma, Dawei Zhang   +6 more
doaj   +1 more source