Results 121 to 130 of about 453,721 (346)

Molecular assays and point-of-care tools: a review of amplification methods and nucleic acid detection systems [PDF]

Anais da Academia Brasileira de Ciências
Molecular diagnosis is crucial for combating infectious diseases due to its high sensitivity and precision. However, its application in point-of-care testing (POCT) faces challenges, particularly in remote areas and developing countries.
VALTEMAR F. CARDOSO, CAIO C. DE SOUZA, JULIANE C. GLÓRIA, ELIZA RAQUEL D. DA SILVA, ARIAMNA MARÍA DIP GANDARILLA, WALTER RICARDO BRITO, LUIS ANDRÉ M. MARIÚBA   +6 more
doaj   +2 more sources

ViCTree: an automated framework for taxonomic classification from protein sequences [PDF]

, 2018
Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent.
Adams, Adams, Altschul, Andrew J Davison, Anil S Thanki, Bao, Cotmore, Di Tommaso, Edgar, Fu, Hibbett, Izquierdo-Carrasco, Janet Kelso, Joseph Hughes, Kapli, Katoh, Katoh, Kozlov, Lauber, Löytynoja, Löytynoja, Nishimura, Sejal Modha, Sievers, Simmonds, Simmonds, Smith, Stamatakis, Susan F Cotmore, Thompson, Vilella, Wu   +31 more
core   +1 more source

Usability of the kink parameters for nucleic acid structure in Database [PDF]

Nucleic Acids Symposium Series, 2005
DNA/RNA molecules with the specific three-dimensional structure, express the specific structural and biological functions. The knowledge integration based on three dimensional structures can be used to explain biochemical observations, to predict biological functions and to design drugs specific to a given complex system.
openaire   +2 more sources

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum

BMC Genomics, 2007
Background Expressed sequence tags (ESTs) have been used for rapid gene discovery in a variety of organisms and provide a valuable resource for whole genome annotation. Although the genome of one marsupial, the opossum Monodelphis domestica, has now been
Miller Robert D, Lindblad-Toh Kerstin, Rosenberg George H, Nyberg April M, Indiviglio Sandra, Baker Michelle L, Papenfuss Anthony T   +6 more
doaj   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

ARTEM: a method for RNA and DNA tertiary motif identification with backbone permutations

Genome Biology
Non-coding RNA functions are largely defined by their 3D structures, which consist of recurrent building blocks, tertiary motifs. The computational motif search problem remains largely unsolved, as standard approaches are restrained by sequence ...
Eugene F. Baulin, Davyd R. Bohdan, Dawid Kowalski, Milena Serwatka, Julia Świerczyńska, Zuzanna Żyra, Janusz M. Bujnicki   +6 more
doaj   +1 more source

Characteristics of the tree shrew gut virome.

PLoS ONE, 2019
The tree shrew (Tupaia belangeri) has been proposed as an alternative laboratory animal to primates in biomedical research in recent years. However, characteristics of the tree shrew gut virome remain unclear.
Linxia Chen, Wenpeng Gu, Chenxiu Liu, Wenguang Wang, Na Li, Yang Chen, Caixia Lu, Xiaomei Sun, Yuanyuan Han, Dexuan Kuang, Pinfen Tong, Jiejie Dai   +11 more
doaj   +1 more source

In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression

BMC Microbiology, 2005
BackgroundMore than 200 studies related to nucleic acid amplification (NAA) tests to detect Mycobacterium tuberculosis directly from clinical specimens have appeared in the world literature since this technology was first introduced.
L. Flores, M. Pai, J. Colford, L. Riley
semanticscholar   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source