Results 161 to 170 of about 453,721 (346)

AGMIAL: implementing an annotation strategy for prokaryote genomes as a distributed system [PDF]

, 2006
We have implemented a genome annotation system for prokaryotes called AGMIAL. Our approach embodies a number of key principles. First, expert manual annotators are seen as a critical component of the overall system; user interfaces were cyclically ...
Bessières, P., Bossy, R., Bryson, K., Chaillou, S., Gibrat, J.-F., Hoebeke, M., Loux, V., Maguin, E., Nicolas, P., Penaud, S., van de Guchte, M.   +10 more
core  

Introduction on Several Popular Nucleic Acids Databases

Journal of Computer Engineering and Informatics, 2013
Nucleic acids are major biological molecules essential for life, and everyday, there are large number of nucleic acids sequences that are released and searched. Now, many nucleic acids databases were used to assembly and distribute structural information related nucleic acids on the internet.
openaire   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Utilization of tmRNA sequences for bacterial identification

, 2001
In recent years, molecular approaches based on nucleotide sequences of ribosomal RNA (rRNA) have become widely used tools for identification of bacteria [1-4].
Amann, R., Kulakauskas, S., Le Bourhis, G., Schönhuber, W., Tremblay, J.   +4 more
core  

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

CoSMIC: A hybrid approach for large-scale, high-resolution microbial profiling of novel niches.

PLoS ONE
Standard microbial profiling based on 16S rRNA (16S) sequencing suffers from a lack of primer universality, primer biases, and often yields low resolution.
Maor Knafo, Shahar Rezenman, Tal Idan, Michael Elgart, Shlomi Dagan, Vered Zavaro, Ziv Reich, Ruti Kapon, Dagan Sade, Noam Shental   +9 more
doaj   +1 more source

Where differences resemble: sequence-feature analysis in curated databases of intrinsically disordered proteins [PDF]

, 2018
Apweiler, Bardou, Brown, Damiano Piovesan, Das, Daughdrill, Dinkel, Dunker, Dunker, Dunker, Dyson, Fichó, Fu, Fukuchi, Gunasekaran, Holehouse, Lee, Marco Necci, Miskei, Mészáros, Necci, Necci, Peng, Piovesan, Piovesan, Piovesan, Radivojac, Receveur-Bréchot, Schad, Silvio C E Tosatto, The Gene Ontology Consortium, Tompa, Uversky, Van Roey, Vucetic, Ward, Wootton, Wright, Xue   +38 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source