Results 81 to 90 of about 52,865,053 (238)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Scalable Approach for Efficiently Generating Structured Dataset Topic Profiles

, 2014
The increasing adoption of Linked Data principles has led to an abundance of datasets on the Web. However, take-up and reuse is hindered by the lack of descriptive information about the nature of the data, such as their topic coverage, dynamics or evolution. To address this issue, we propose an approach for creating linked dataset profiles.
Besnik Fetahu, Stefan Dietze, Bernardo Pereira Nunes, Marco Antonio Casanova, Davide Taibi 0002, Wolfgang Nejdl   +5 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hybrid topic modeling method based on dirichlet multinomial mixture and fuzzy match algorithm for short text clustering

Journal of Big Data
Topic modeling methods proved to be effective for inferring latent topics from short texts. Dealing with short texts is challenging yet helpful for many real-world applications, due to the sparse terms in the text and the high dimensionality ...
Mutasem K. Alsmadi, Malek Alzaqebah, Sana Jawarneh, Ibrahim ALmarashdeh, Mohammed Azmi Al-Betar, Maram Alwohaibi, Noha A. Al-Mulla, Eman AE Ahmed, Ahmad AL Smadi   +8 more
doaj   +1 more source

Software framework for hyperparameters optimization of models with additive regularization

Научно-технический вестник информационных технологий, механики и оптики
The processing of unstructured data, such as natural language texts, is one of the urgent tasks in the development of intelligent products. In turn, topic modeling as a method of working with unmarked and partially marked text data is a natural choice ...
M. A. Khodorchenko, N. A. Butakov, D. A. Nasonov, M. Yu. Firulik   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

AZIM: Arabic-Centric Zero-Shot Inference for Multilingual Topic Modeling With Enhanced Performance on Summarized Text

IEEE Access
Topic modeling is an unsupervised learning technique, that is extensively used for discovering latent topics in huge text corpora. However, existing models often fall short in cross-lingual scenarios, particularly for morphologically rich and low ...
Sania Aftar, Abdul Rehman, Sonia Bergamaschi, Luca Gagliardelli   +3 more
doaj   +1 more source

Bibliometric Analysis to Scan and Scrape New Datasets: It’s all about that BASS

International Journal of Population Data Science, 2017
Objectives The main objective of this poster is to present a pilot project in determining emerging population health themes and identifying key research-enabling datasets ahead of time.
Karen Tingay, Brian Perkins, Athanasios Anastasiou   +2 more
doaj   +1 more source

TwiInsight: Discovering Topics and Sentiments from Social Media Datasets

CoRR, 2017
Social media platforms contain a great wealth of information which provides opportunities for us to explore hidden patterns or unknown correlations, and understand people's satisfaction with what they are discussing. As one showcase, in this paper, we present a system, TwiInsight which explores the insight of Twitter data.
Zhengkui Wang, Guangdong Bai, Soumyadeb Chowdhury, Quanqing Xu, Zhi Lin Seow   +4 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source