Results 51 to 60 of about 53,590 (235)

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line

International Journal of Nanomedicine, 2012
Jian Cheng,1,* Lin Cheng,1,* Baoan Chen,1,2 Guohua Xia,1 Chong Gao,1 Huihui Song,1 Wen Bao,1 Qinglong Guo,3 Haiwei Zhang,3 Xuemei Wang41Department of Hematology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast ...
Cheng J, Cheng L, Chen B, Xia G, Gao C, Song H, Bao W, Guo Q, Zhang H, Wang X   +9 more
doaj  

In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells

Brazilian Journal of Medical and Biological Research, 2001
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors.
P.E. Dorlhiac-Llacer, M.V. Marquezini, O. Toffoletto, R.C.G. Carneiro, R.C. Maranhão, D.A.F. Chamone   +5 more
doaj   +1 more source

Spectrofluorimetric Determination of Daunorubicin Using Terbium-Deferasirox as a Fluorescence Probe [PDF]

شیمی کاربردی روز, 2015
A spectrofluorimetric method is proposed for the determination of Daunorubicin (DNR) based on its quenching effect on the fluorescence intensity of Tb3+- deferasirox (DFX) complex as a fluorescent probe.
جمشید منظوری لشگر, نوید نیائی, جعفر ابوالحسنی   +2 more
doaj   +1 more source

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]

, 2017
Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre, Alexander Bukreyev, Ana Fernandez-Sesma, Benjamin C. Yen, Bersabeh Tigabu, Christopher F. Basler, Colette A. Pietzsch, Daisy W. Leung, Lorraine K. Morlock, Maria T. Sanchez-Aparicio, Noelle S. Williams, Priya Luthra, Sebastian Aguirre, Terence S. Dermody   +13 more
core   +3 more sources

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Intensive Chemotherapy With or Without Midostaurin in Adults ≥ 60 Years Old With FLT3-Mutated AML: A FILO-DATAML-PETHEMA Real-World Study. [PDF]

Am J Hematol
ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Aspas Requena G, Montesinos P, Bérard E, Bertoli S, Rodríguez-Veiga R, Simand C, Torres L, Peterlin P, Tormo M, Birsen R, Bergua-Burgues JM, Tavernier E, Bernal Del Castillo T, Carré M, Gil C, Contejean A, Rodríguez-Arbolí E, Orvain C, Rodríguez-Medina C, Veronese L, Sayas Lloris MJ, Delabesse E, Serrano J, Mineur A, García-Fortes M, Guieze R, Amigo ML, Pigneux A, Algarra Algarra L, Recher C, Dumas PY, Martínez-Cuadrón D.   +31 more
europepmc   +2 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Anthracycline Induced Cardiac Disorders in Childhood Acute Lymphoblastic Leukemia: A Single-Centre, Retrospective, Observational Study

Frontiers in Pharmacology, 2021
Anthracycline-associated cardiotoxicity is frequently seen in cancer survivors years after treatment, but it is rare in patients on chemotherapy. This study aimed to investigate the clinical characteristics of cardiac disorders in children with acute ...
Hui Yu, Yining Qiu, Hui Yu, Zhujun Wang, Jiawei Xu, Yun Peng, Xia Wan, Xiaoyan Wu, Runming Jin, Fen Zhou   +9 more
doaj   +1 more source

Liposomes as a model for the biological membrane : studies on daunorubicin bilayer interaction [PDF]

, 2012
In this study the interaction of the antitumoral drug daunorubicin with egg phosphatidylcholine (EPC) liposomes, used as a cell membrane model, was quantified by determination of the partition coefficient (Kp).
A Leo, AP Winiski, B Castro, C Hansch, C Heywang, C Matos, C Peetla, Carla Matos, Carla Moutinho, CWF McClare, EK Rooney, H Ferreira, H Ferreira, J Marcelino, KA Edwards, L Gallois, L Gallois, M Eisenberg, M Ratna, Paulo Lobão, S McLaughlin, S Takegami, SH White, SR Dipali, V Agrawal, Y Romsicki   +25 more
core   +2 more sources