Results 31 to 40 of about 53,590 (235)

Interactions of Cisplatin and Daunorubicin at the chromatin level [PDF]

, 2020
Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro.
Bacsó, Zsolt, Firouzi Niaki, Erfaneh, Imre, László, Nánási, Péter Jr., Szabó, Gábor, Tarapcsák, Szabolcs, Van Acker, Thibaut, Vanhaecke, Frank   +7 more
core   +2 more sources

Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia

BMC Cancer, 2019
Background Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following exposure to daunorubicin and to ...
Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley   +5 more
doaj   +1 more source

Integrated Molecular Risk Stratification and Measurable Residual Disease-Guided Consolidation Improve Outcomes in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia. [PDF]

Cancer Med
This multicenter study demonstrates that integrating molecular risk stratification with MRD‐guided consolidation improves outcomes in pediatric non‐DS‐AMKL. Specifically, HSCT in the first complete remission provides a significant survival advantage over chemotherapy for patients with high‐risk genetics or suboptimal induction response.
Cai C, Chen Y, Wu C, Feng X, Li C, Zheng M, Mai H, Yang L, Jiang H, He X, Wen H, Xu H, Chen C, Le S, Li N, Zheng Y.   +15 more
europepmc   +2 more sources

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

Frontiers in Immunology, 2017
Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP.
Mariangela Lecciso, Darina Ocadlikova, Sabina Sangaletti, Sara Trabanelli, Elena De Marchi, Elisa Orioli, Anna Pegoraro, Paola Portararo, Camilla Jandus, Andrea Bontadini, Annarita Redavid, Valentina Salvestrini, Pedro Romero, Mario P. Colombo, Francesco Di Virgilio, Michele Cavo, Elena Adinolfi, Antonio Curti   +17 more
doaj   +1 more source

Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin [PDF]

, 1985
In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cytotoxic ...
Feijen, J., Greve, J., Grooth, B.G. de, Heeswijk, W.A.R., Hoes, C.J.T., Mud, J., Potman, W.   +6 more
core   +2 more sources

Possible Cardio-protective Effects of TND1128 and Omega-3 Fatty Acids Against Daunorubicin-Induced Cardiotoxicity in Male Wistar Rats: A Comparative In Vivo Study [PDF]

Pharmaceutical Sciences
Background: Daunorubicin, an anthracycline antibiotic widely used in chemotherapy, is limited due to its dose-dependent cardiotoxicity. Omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) provide
Huda Hameed Rasheed, Alaa Radhi Khudhair
doaj   +1 more source

pH-Sensitive Liposomes for Enhanced Cellular Uptake and Cytotoxicity of Daunorubicin in Melanoma (B16-BL6) Cell Lines

Pharmaceutics, 2022
Daunorubicin (DNR) was delivered using a pH-sensitive liposomal system in B16-BL6 melanoma cell lines for enhanced cytotoxic effects. DNR was encapsulated within liposomes and CL as a component of the lipid bilayer.
Hamad Alrbyawi, Ishwor Poudel, Manjusha Annaji, Sai H. S. Boddu, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu   +6 more
doaj   +1 more source

Applicability of the National Comprehensive Cancer Network/Multinational Association of Supportive Care in Cancer Guidelines for Prevention and Management of Chemotherapy-Induced Nausea and Vomiting in Southeast Asia: A Consensus Statement. [PDF]

, 2017
A meeting of regional experts was convened in Manila, Philippines, to develop a resource-stratified chemotherapy-induced nausea and vomiting (CINV) management guideline. In patients treated with highly emetogenic chemotherapy in general clinical settings,
Abdullah, Matin M, Chan, Alexandre, Ishak, Wan Zamaniah B Wan, Kanesvaran, Ravindran, Ong-Cornel, Annielyn B, Villalon, Antonio H   +5 more
core   +2 more sources

Performance of Pristine versus Magnetized Orange Peels Biochar Adapted to Adsorptive Removal of Daunorubicin: Eco-Structuring, Kinetics and Equilibrium Studies

Nanomaterials, 2023
Drugs and pharmaceuticals are an emergent class of aquatic contaminants. The existence of these pollutants in aquatic bodies is currently raising escalating concerns because of their negative impact on the ecosystem.
Ahmed S. El-Shafie, Farahnaz G. Barah, Maha Abouseada, Marwa El-Azazy   +3 more
doaj   +1 more source

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. [PDF]

, 2012
BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system.
de Vere White, Ralph, Gao, Tingjuan, Lam, Kit S, Lara, Primo N, Li, Yuanpei, Lin, Tzu-Yin, Luo, Juntao, Pan, Chong-Xian, Zhang, Hongyong   +8 more
core   +2 more sources