Results 11 to 20 of about 36,964 (190)
Daunorubicin metabolism: estimation of daunorubicin reductase [PDF]
British Journal of Pharmacology, 1971 Summary Daunorubicin reductase, an enzyme ubiquitous in all mammalian tissues tested, converts daunorubicin, a cancer chemotherapeutic antibiotic, to daunorubicinol. A method for the estimation of daunorubicinol and daunorubicin reductase is described.
N R, Bachur, D H, Huffman
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Pharmaceutics, 2022 Daunorubicin pharmacokinetics (PK) are characterised by an important inter-individual variability, which raises questions about the optimal dose regimen in patients with acute myeloid leukaemia.
Guillaume Drevin +12 more
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Self‐association of daunorubicin [PDF]
FEBS Letters, 1974 with cytoxic and antimitotic activities. Presently it is used in the treatment of acute leukemia [ 1 ] . A considerable body of evidence has been accum- ulated which is in agreement with the existence of an intercalative complex with the DNA [2], which results in inhibition of both enzymatic RNA and DNA synthesis [3,4].
Barthelemy-Clavey, Véronique +3 more
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Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment
BMC Cancer, 2021 Background Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes of cell death, including apoptosis.
Hussain Mubarak Al-Aamri +3 more
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Effects of Royal Jelly on Apoptosis and the Expression of Apoptotic Genes on Testicular Tissue in Male Balb/C Mice Treated with Daunorubicin [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Daunorubicin is an effective drug in chemotherapy, but its clinical use is limited due to serious side effects. Royal jelly as a natural compound obtained from bees can be helpful in preventing the damage caused by daunorubicin ...
Mansour Safaei Pourzamani +4 more
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Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. [PDF]
PLoS ONE, 2016 Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear.
Akihiro Watari +3 more
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Artificial Cells, Nanomedicine, and Biotechnology, 2021 Brain glioma is the most common primary tumour of the central nervous system. Complete surgical removal of the brain glioma is virtually impossible. Chemotherapy is still an important treatment for brain glioma.
Hong-Jun Xie +6 more
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Journal of Pharmacological Sciences, 2005 The purpose of this study was to investigate the effects of daunorubicin on lipopolysaccharide (LPS)-stimulated inducible-type nitric oxide synthase (iNOS) expression in macrophages.
Fumiaki Saito +3 more
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Pharmaceutics, 2023 The aim of this study was to develop casein-based nanoscale carriers as a potential delivery system for daunorubicin, as a pH-responsive targeting tool for acute lymphocytic leukemia.
Nikolay Zahariev +3 more
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Oxaliplatin combined with daunorubicin induces apoptosis of colon cancer cell line HT-29 [PDF]
Jichu yixue yu linchuang, 2020 Objective To study the mechanism of oxaliplatin combined with daunorubicin on the apoptosis of colon cancer cells. Methods Colon cancer cells HT-29 were incubated with different concentrations of oxaliplatin and daunorubicin respectively, MTT assay was ...
TIAN Chun-yang, LIU Xiao-zheng, FAN Jun-chao
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