Results 141 to 150 of about 4,166 (290)

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +2 more sources

A review of metal-ion-flux-controlled growth of metastable TiAlN by HIPIMS/DCMS co-sputtering

, 2014
We review results on the growth of metastable Ti1-xAlxN alloy films by hybrid high-power pulsed and dc magnetron co-sputtering (HIPIMS/DCMS) using the time domain to apply substrate bias either in synchronous with the entire HIPIMS pulse or just the ...
Schiffers, Ch.,, Greczynski, Grzegorz, Hultman, Lars, Jensen, Jens,, Lemmer, O.,, Schiffers, Ch., Hultman, Lars,, Lu, Jun,, Greene, Joseph E, Greene, Joseph E,, Lemmer, O., Koelker, W.,, Bolz, S.,, Bolz, S., Greczynski, Grzegorz,, Lu, Jun, Jensen, Jens, Koelker, W.   +17 more
core   +1 more source

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin‐induced diabetes rat model

Animal Models and Experimental Medicine, EarlyView.
Daily insulin administration in streptozotocin‐induced diabetic rats prevented cardiac damage associated with diabetic cardiomyopathy, including hypertrophy, fibrosis, and expression of cell death markers, at 12 weeks. However, cyclophilin D, a marker of mitochondrial permeability transition pore‐opening‐associated cell death (necrosis), was observed ...
Tamara Sáez, Ivo Carrasco‐Wong, Juan Varas, Sebastián San Martín, Jaime A. Riquelme, Rienzi Díaz‐Navarro   +5 more
wiley   +1 more source

Valency‐Controlled Multiphotochromism: Gated Switching and Photoswitchable Lewis Superacidity at Silicon

Angewandte Chemie, EarlyView.
Multiphotochromic switching is controlled by silicon valency in a diarylethene‐based molecular architecture. Lewis base coordination gates electronic communication between the photochromic units, thereby enabling selective access to distinct switching states.
Lennart Stoess, Valentin D. Hannibal, Lutz Greb   +2 more
wiley   +2 more sources

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +2 more sources

Enantioselective Synthesis of Axially Chiral Diaryl Ethers via Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition

Angewandte Chemie, EarlyView.
An enantioselective rhodium‐catalyzed [2 + 2 + 2] cycloaddition enables the synthesis of axially chiral diaryl ethers. Carbonyl coordination ensures high reactivity and regioselectivity, affording products bearing up to four stereogenic axes with good enantio‐ and diastereoselectivity.
Yu Sato, Julong Jiang, Kairi Yamashiro, Ken Tanaka   +3 more
wiley   +2 more sources

Tuning microstructure and mechanical properties in superstoichiometric to substoichiometric TiB₂ thin films: a DCMS and HiPIMS study

Controlling the mechanical performance of TiB₂-based coatings is challenging due to the complex interplay between chemical composition, texture, microstructure, and residual stress.
Wojcik, T.; orcid:, Mayrhofer, P.H.; orcid:, Kirnbauer, Alexander; orcid:, Astecker, Thomas, Limbeck, Andreas; orcid:, Podsednik, Maximilian, Enzlberger, Ludwig; orcid:, Kolozsvári, Szilard; orcid:   +7 more
core   +1 more source

Auf dem Weg zu chromoselektiven Transformationen in biologischen Systemen: Perspektiven und Herausforderungen

Angewandte Chemie, EarlyView.
Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley   +1 more source

Enzyme‐Like Synthetic Cleft for Light‐Driven Water‐Oxidation Catalysis Via an Oxide Relay Pathway

Angewandte Chemie, EarlyView.
A carboxylic acid group introduced into the second coordination sphere of a Ru(bda) water oxidation catalyst forms a defined hydrogen bond within the catalytic cleft. This interaction locks the group in place and enables an intramolecular oxide relay pathway between Ru(V)═O and the carboxylate group, providing a distinct and efficient route for O─O ...
Daniel A. P. Friedewald, Gourab Das, Philipp H. Kirchner, Olga Anhalt, Deqi Tang, Sandra Luber, Florian Beuerle, Frank Würthner   +7 more
wiley   +2 more sources

Result table of model-based estimation in DCMs.

Over recent decades, machine learning, an integral subfield of artificial intelligence, has revolutionized diverse sectors, enabling data-driven decisions with minimal human intervention.
Yun Joo Yoo (17743270), Gahgene Gweon (17018078), Ji-Young Yoon (685712)   +2 more
core   +1 more source