Results 41 to 50 of about 14,085 (196)
Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress
Current Issues in Molecular Biology, 2023 Oxidative stress is known to influence mRNA levels, translation, and proteolysis. The importance of oxidative stress has been demonstrated in several human diseases, including neurodegenerative disorders.
Nikolaos S. Lotsios +7 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Geophysical Monograph Series, Page i-xiv., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
wiley +1 more source
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Growing Degree‐Day Trends Associated With ‘False Springs’ in the Continental United States
International Journal of Climatology, EarlyView.Earlier spring warming has increased growing degree‐day (GDD) accumulation prior to the last freeze at some US locations (red circles = stat. sig. increases). However, after accounting for spatial autocorrelation using a false discovery rate approach, few trends remain significant, indicating no coherent continental‐scale increase in false spring risk.
Robert E. Davis +3 more
wiley +1 more source
Optimization of Diffusion MRI With Consideration of the Signal Decay in Biological Tissues
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Devising methodology to characterize and optimize acquisition schemes for biological tissues, such as the prostate, that produce model‐based synthetic diffusion‐weighted images and derived model parameters with predictable SNR improvement. Methods The averaging effect (AE) in synthetic diffusion‐weighted images obtained through fitting
Stefan Kuczera, Stephan E. Maier
wiley +1 more source
Media and CommunicationContemporary political campaigning takes place both online and offline, and can be data-driven. In this piece, we review existing knowledge around data-driven campaigning (DDC) and introduce the new contributions made by the pieces within this thematic ...
Stephanie Luke +5 more
doaj +1 more source
Evidence Based Library and Information Practice, 2019 A Review of: Lund, B., & Agbaji, D. (2018). Use of Dewey Decimal Classification by academic libraries in the United States. Cataloging and Classification Quarterly, 56(7), 653-661.
Jordan Patterson
doaj +1 more source