Results 131 to 140 of about 190,243 (246)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang   +7 more
wiley   +1 more source

Salt‐Freshwater Mixing and Submarine Groundwater Discharge in Sloping Unconfined Tidal Aquifers

open access: yesGeophysical Research Letters, Volume 53, Issue 3, 16 February 2026.
Abstract Previous studies have revealed the groundwater flow and salt transport in unconfined coastal aquifers in response to numerous factors. However, previous studies assumed a flat aquifer base, and it is unclear how a sloping aquifer base would affect the subsurface flow and salinity distributions.
Chengji Shen   +5 more
wiley   +1 more source

Advanced Branched Carbon Nanotube/Carbon Black Hybrid Technologies: Cost‐Effective Fabrication of High‐Performance Conductive Polyamide 6 Filaments for Next‐Generation Smart Textile Applications

open access: yesAdvanced Materials Technologies, Volume 11, Issue 3, 5 February 2026.
This study demonstrates a cost‐effective hybrid nanofiller approach for developing conductive polyamide 6 filaments via melt spinning. Branched carbon nanotubes combined with carbon black create synergistic networks where spherical CB particles bridge aligned CNTs, maintaining electrical pathways during fiber drawing.
Müslüm Kaplan   +3 more
wiley   +1 more source

DDRed in Liberia: Youth Remarginalisation or Reintegration? [PDF]

open access: yes
This report questions mainstream approaches to the reintegration of youthful ex-combatants. In Liberia, the disarmament and demobilisation was implemented quite effectively, but several questions can be asked about the components of reintegration and ...
Ingunn Bjørkhaug, Morten Bøås
core  

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian   +11 more
wiley   +1 more source

AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.
ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick   +8 more
wiley   +1 more source

Untargeted Metabolomics Reveals Seasonal and Tissue‐Specific Metabolic Shifts in Holothuria cinerascens

open access: yesChemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Untargeted metabolic profiling of three body tissues from Holothuria cinerascens in South Africa using 1H‐NMR and UPLC–QTOF–MS revealed distinct tissue‐specific and seasonal metabolic variations, with the body wall and gut/mesentery exhibiting high metabolite diversity.
Cassandra Upton   +3 more
wiley   +1 more source

WRAP53 is Downregulated in Acute Myeloid Leukemia Patients and Positively Correlates With HTERT Expression

open access: yesCancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Acute myeloid leukemia (AML) is a prevalent hematologic malignancy in adults, marked by clonal disorders in hematopoietic cells, rapid progression, and genetic heterogeneity. The WRAP53 gene, which is associated with genomic stability due to its involvement in activities, such as DNA repair, TP53 regulation, and association with ...
Renan Brito Gadelha   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy