Results 61 to 70 of about 152,624 (261)
Gossamer — a resource-efficient de novo assembler [PDF]
Bioinformatics, 2012 Abstract Motivation: The de novo assembly of short read high-throughput sequencing data poses significant computational challenges. The volume of data is huge; the reads are tiny compared to the underlying sequence, and there are significant numbers of sequencing errors.
Thomas C. Conway +4 more
openaire +2 more sources
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Bandage: interactive visualisation of de novo genome assemblies [PDF]
Bioinformatics, 2015 Abstract Summary While de novo assembly graphs contain assembled contigs (nodes), the connections between those contigs (edges) are difficult for users to access. Bandage (a B ioinformatics
Ryan R. Wick +3 more
openaire +3 more sources
Advanced Engineering Materials, EarlyView.In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley +1 more source
Bio‐Inspired Synthesis of Macroporous Single Crystal Particles as Scattering Agents
Advanced Functional Materials, EarlyView.A general strategy is presented that delivers unique, single‐crystal microparticles that combine submicron macroporosity and uniform particle shapes. A bioinspired approach is used to occlude three distinct types of additives – polystyrene microspheres, polymer vesicles and amino acids – within calcite single crystals, and subsequent thermal annealing ...
Stephanie E. Foster +11 more
wiley +1 more source
Plant assemble - Plant de novo genome assembly: assembly v2
, 2022 With the advancement of long-read sequencing technologies and associated bioinformatics tools, it has now become possible to de novo assemble complex plant genomes with unrivalled contiguity, completeness and correctness. As read lengths can surpass repeat lengths, the ability to assemble genomes de novo has dramatically improved, whereby complex plant
Scott Ferguson +2 more
openaire +1 more source
Advanced Healthcare Materials, EarlyView.A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka +2 more
wiley +1 more source
NxRepair: error correction in de novo sequence assembly using Nextera mate pairs [PDF]
PeerJ, 2015 Scaffolding errors and incorrect repeat disambiguation during de novo assembly can result in large scale misassemblies in draft genomes. Nextera mate pair sequencing data provide additional information to resolve assembly ambiguities during scaffolding ...
Rebecca R. Murphy +3 more
doaj +2 more sources
Complete De Novo Assembly of Monoclonal Antibody Sequences [PDF]
Scientific Reports, 2016 AbstractDe novo protein sequencing is one of the key problems in mass spectrometry-based proteomics, especially for novel proteins such as monoclonal antibodies for which genome information is often limited or not available. However, due to limitations in peptides fragmentation and coverage, as well as ambiguities in spectra interpretation, complete de
Ngoc Hieu Tran +5 more
openaire +2 more sources