Results 51 to 60 of about 334,258 (285)

NSIT: novel sequence identification tool. [PDF]

PLoS ONE, 2014
Novel sequences are DNA sequences present in an individual's genome but absent in the human reference assembly. They are predicted to be biologically important, both individual and population specific, and consistent with the known human migration paths.
Benjarath Pupacdi, Asif Javed, Mohammed J Zaki, Mathuros Ruchirawat   +3 more
doaj   +1 more source

A microfluidic oligonucleotide synthesizer [PDF]

, 2010
De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods.
Lee, Cheng-Chung, Quake, Stephen R., Snyder, Thomas M.   +2 more
core   +4 more sources

Scaling metagenome sequence assembly with probabilistic de Bruijn graphs

, 2012
Deep sequencing has enabled the investigation of a wide range of environmental microbial ecosystems, but the high memory requirements for {\em de novo} assembly of short-read shotgun sequencing data from these complex populations are an increasingly ...
A. Hintze, A. Howe, C. T. Brown, Compeau, Gans, Gilbert, Gilbert, Grabherr, Hess, Iqbal, J. M. Tiedje, J. Pell, Kelley, Liu, Mackelprang, Melsted, Miller, Pevzner, Price, Qin, R. Canino-Koning, Shi, Wooley, ZHANG   +23 more
core   +1 more source

REAPR: a universal tool for genome assembly evaluation. [PDF]

, 2013
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked.
Berriman, Matthew, Hunt, Martin, Kikuchi, Taisei, Newbold, Chris, Otto, Thomas D, Sanders, Mandy   +5 more
core   +2 more sources

Genome assembly using quantum and quantum-inspired annealing

Scientific Reports, 2021
Recent advances in DNA sequencing open prospects to make whole-genome analysis rapid and reliable, which is promising for various applications including personalized medicine.
A. S. Boev, A. S. Rakitko, S. R. Usmanov, A. N. Kobzeva, I. V. Popov, V. V. Ilinsky, E. O. Kiktenko, A. K. Fedorov   +7 more
doaj   +1 more source

De novo assembly of the cattle reference genome with single-molecule sequencing. [PDF]

, 2020
BackgroundMajor advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated ...
Bickhart, Derek M, Cole, John B, Couldrey, Christine, Dreischer, Christian, Elsik, Christine G, Ghurye, Jay, Hagen, Darren E, Hall, Richard, Hammond, John A, Hoffman, Jinna, Koren, Sergey, Li, Wenli, Liu, George, Low, Wai Y, McDaneld, Tara G, McKay, Stephanie D, Medrano, Juan F, Murdoch, Brenda M, Nandolo, Wilson, Phillippy, Adam M, Rhie, Arang, Rosen, Benjamin D, Rowan, Troy N, Schnabel, Robert D, Schroeder, Steven G, Schultheiss, Sebastian J, Schwartz, John C, Smith, Timothy PL, Snelling, Warren M, Thibaud-Nissen, Françoise, Tseng, Elizabeth, Van Tassell, Curtis P, Zimin, Aleksey   +32 more
core  

SIMBA: a web tool for managing bacterial genome assembly generated by Ion PGM sequencing technology [PDF]

, 2016
Background The evolution of Next-Generation Sequencing (NGS) has considerably reduced the cost per sequenced-base, allowing a significant rise of sequencing projects, mainly in prokaryotes. However, the range of available NGS platforms requires different
Aguiar, Edgar L., Azevedo, Vasco A. C., Barh, Debmalya, Benevides, Leandro, Figueiredo, Henrique C. P., Folador, Edson L., Ghosh, Preetam, Guimarães, Luís C., Mariano, Diego C. B., Oliveira, Letícia C., Pereira, Felipe L., Ramos, Rommel T. J., Silva, Artur, Sousa, Thiago J.   +13 more
core   +3 more sources

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic [PDF]

, 2016
Peptide-based structures can be designed to yield artificial proteins with specific folding patterns and functions. Template-based assembly of peptide units is one design option, but the use of two orthogonal self-assembly principles, oligonucleotide ...
Christensen, Niels Johan, Jensen, Knud J, Kjems, Jørgen, Lou, Chenguang, Madsen, Charlotte S, Martos-Maldonado, Manuel C, Midtgaard, Søren Roi, Thomsen, Rasmus P, Thulstrup, Peter W, Wengel, Jesper   +9 more
core   +2 more sources

Yet another de novo genome assembler [PDF]

2019 11th International Symposium on Image and Signal Processing and Analysis (ISPA), 2019
AbstractAdvances in sequencing technologies have pushed the limits of genome assemblies beyond imagination. The sheer amount of long read data that is being generated enables the assembly for even the largest and most complex organism for which efficient algorithms are needed.
Vaser, Robert, Šikić, Mile
openaire   +2 more sources

De novo design of allosterically switchable protein assemblies

Nature, 2023
Allosteric modulation of protein function, wherein the binding of an effector to a protein triggers conformational changes at distant functional sites, plays a central role in the control of metabolism and cell signaling1–3. There has been considerable interest in designing allosteric systems, both to gain insight into the mechanisms underlying such ...
Arvind Pillai, Abbas Idris, Annika Philomin, Connor Weidle, Rebecca Skotheim, Philip J. Y. Leung, Adam Broerman, Cullen Demakis, Andrew J. Borst, Florian Praetorius, David Baker   +10 more
openaire   +2 more sources