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Kinetics of N-acetylprocainamide deacetylation
Clinical Pharmacology and Therapeutics, 1980The kinetics of N-acetylprocainamide (NAPA) deacetylation to procainamide (PA) were determined in a normal subject using NAPA-13C, labeled in the acetyl group. The deacetylation clearance of NAPA (ClD) was found to be 6.5 ml/min whereas total NAPA elimination clearance was 231 ml/min, so that 2.8% of the administered NAPA-13C was metabolized by ...
G P, Stec +5 more
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Histone Acetylation and Histone Deacetylation
Molecular Biotechnology, 2002Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation--increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II.
Kazuhiro, Ito, Ian M, Adcock
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Chemical Acetylation and Deacetylation
2013Lysine acetylation is an important posttranslational modification known to alter protein structure and function. Understanding the mechanisms involved in regulating protein acetylation remains a key factor in elucidating what role this modification plays in numerous disease pathologies.
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Enzymatic deacetylation of galactoglucomannans
Applied Microbiology and Biotechnology, 1993Several hemicellulolytic microorganisms were screened for their capability of liberating acetyl side groups from native softwood galactoglucomannan. All the microorganisms tested were found to produce an extracellular acetyl glucomannan esterase(s). The highest activity was detected in Schizophyllum commune culture filtrate.
Puls, Jürgen +4 more
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Deacetylation Regioselective De Glycals
Journal of Carbohydrate Chemistry, 1991ABSTRACT Hydrazine acetate is shown to effect selective deacetylation on peracetylated glycals like D-xylal, D-glucal, D-galactal and L-rhamnal. It is demonstrated that the observed selectivity on the -4 position cannot be explained by acetyl migration during the reaction.
Salah Bouhroum +6 more
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Deacetylation of phenacetin by liver esterase
Biochemical Pharmacology, 1965Abstract Microsomal liver esterase cleaves the amide bond of the phenacetin molecule in vitro yielding p -phenetidine and acetic acid as reaction products. Some kinetic data of this reaction are reported. N-acetyl- p -aminobenzoic acid, being more polar than acetanilide, is hydrolysed about 1000 times slower by the isolated enzyme.
E, Bernhammer, K, Krisch
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Histone Acetylation and Deacetylation
2012Gene expression in eukaryotic organisms can be influenced by a host of internal and external stimuli. The magnitude and duration of the response can often determine the effect of a diverse array of biological functions, many of which can be driven by gene expression.
Daniel M. Fass +5 more
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Stimulating Movement by Deacetylation
Science's STKE, 2002Acetylated tubulin is associated with stable microtubule structures. Hubbert et al. identified a member of the histone deacetylase (HDAC) family HDAC6 as a deacetylase that colocalized with microtubules in cells. Overexpression of HDAC6 in NIH 3T3 cells promoted deacetylation of α-tubulin.
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Enzymatic Deacetylation of Cephalosporins
1978The acetyl esterase from B. subtieis ATCC 6633 is a stable, nonspecific and relatively costly enzyme with a molecular weight of about 150,000 and an activity maximum at pH 8. The Vmax for all substrates examined are typically 110 to 130 µmole/min/mg pure protein; and the values of Km range from 7 to 15 mM for various cephalosporins.
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