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Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma [PDF]

Scientific Reports
Immune checkpoint blockade (ICB) is a commonly used treatment modality for cancer with a growing list of oncologic indications. Ototoxicity is a potential immune-related adverse event of ICB treatment, but the risk of hearing loss after ICB remains ...
Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez   +11 more
doaj   +2 more sources

Empowering the deaf. Let the deaf be deaf [PDF]

Journal of Epidemiology & Community Health, 2000
Deafness is often regarded as just a one and only phenomenon. Accordingly, deaf people are pictured as a unified body of people who share a single problem. From a medical point of view, we find it usual to work with a classification of deafness in which pathologies attributable to an inner ear disorder are segregated from pathologies attributable to an
Muñoz Baell, Irma María, Ruiz Cantero, María Teresa   +1 more
openaire   +4 more sources

Parenting stress and needs for social support in mothers and fathers of deaf or hard of hearing children

Frontiers in Psychology, 2023
IntroductionHearing parents of deaf or hard of hearing (DHH) children may experience parenting stress and social support could be a buffer to this stress. Differences in levels of these two indicators may exist between mothers and fathers.
Amélie Marie, Laëtitia Clabaut, Marjolaine Corbeil, Clémence Vanlerberghe, Catherine Vincent-Delorme, Barbara Le Driant   +5 more
doaj   +1 more source

To Deaf or not to deaf: That is the Question [PDF]

Psychology, 2019
Names are both personal and political, as they relate to identity. Woodward’s 1975 etic article first mentioned a naming convention for D/deaf and prominent scholars have debated the issue since. To evaluate current preferences, the research team used an online questionnaire to gather emic insights and opinions from the community, as well as a more ...
Ju-Lee A. Wolsey, Katrina R. Cue, Kimberly K. Pudans-Smith, M. Diane Clark   +3 more
openaire   +2 more sources

Comprehensive multiomic characterization of human papillomavirus-driven recurrent respiratory papillomatosis reveals distinct molecular subtypes

Communications Biology, 2021
Cem Sievers et al. performed genomic and transcriptomic analysis in human recurrent respiratory papillomatosis (RRP). They found that RRP harbors few genomic alterations, but that distinct transcriptional subtypes correlate with HPV gene expression and ...
Cem Sievers, Yvette Robbins, Ke Bai, Xinping Yang, Paul E. Clavijo, Jay Friedman, Andrew Sinkoe, Scott M. Norberg, Christian Hinrichs, Carter Van Waes, Clint T. Allen   +10 more
doaj   +1 more source

ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

OncoImmunology, 2020
Inhibitor of apoptosis protein (IAP) antagonists have shown activity in preclinical models of head and neck squamous cell carcinoma (HNSCC), and work across several cancer types has demonstrated diverse immune stimulatory effects including enhancement of
Wenda Ye, Sreenivasulu Gunti, Clint T. Allen, Youji Hong, Paul E. Clavijo, Carter Van Waes, Nicole C. Schmitt   +6 more
doaj   +1 more source

Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system

Scientific Reports, 2022
During hair cell development, the mechanoelectrical transduction (MET) apparatus is assembled at the stereocilia tips, where it coexists with the stereocilia actin regulatory machinery.
Angela Ballesteros, Manoj Yadav, Runjia Cui, Kiyoto Kurima, Bechara Kachar   +4 more
doaj   +1 more source

The Effect of Lifetime Noise Exposure and Aging on Speech-Perception-in-Noise Ability and Self-Reported Hearing Symptoms: An Online Study

Frontiers in Aging Neuroscience, 2022
Animal research shows that aging and excessive noise exposure damage cochlear outer hair cells, inner hair cells, and the synapses connecting inner hair cells with the auditory nerve.
Adnan M. Shehabi, Adnan M. Shehabi, Garreth Prendergast, Hannah Guest, Christopher J. Plack, Christopher J. Plack   +5 more
doaj   +1 more source

Transient evoked otoacoustic emissions testing for screening of sensorineural deafness in puppies [PDF]

, 2011
<p><b>Background:</b> Transient evoked otoacoustic emissions (TEOAE) are widely used for human neonatal deafness screening, but have not been reported for clinical use in dogs.</p> <p><b>Hypothesis/Objectives:< ...
Ahlstrom, Branis, De Capua, Doyle, Famula, Hall, Igarashi, Kemp, Korres, Lonsbury-Martin, Lonsbury-Martin, Lurie, Maxon, Platt, Rhodes, Schemera, Sims, Sockalingam, Strain, Strain, Strain, Strain, Ter Haar, Wilkes, Wilson, Wood   +25 more
core   +1 more source

A destressing "deafness" in French? [PDF]

, 1997
French is a language in which accent is mandatory on the last syllable of every content word. In contrast, Spanish uses accent to distinguish different lexical items (e.g., b'ebe vs beb'e).
Dupoux, E., Mehler, J., Pallier, C., Sebastian, N.   +3 more
core   +3 more sources