Results 11 to 20 of about 145,362 (297)

Behavioral models of tinnitus and hyperacusis in animals

Frontiers in Neurology, 2014
The phantom perception of tinnitus and reduced sound level tolerance associated with hyperacusis, have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments.
Sarah H Hayes, Kelly E Radziwon, Daniel J Stolzberg, Richard J Salvi   +3 more
doaj   +1 more source

Characterization of the development of the mouse cochlear epithelium at the single cell level

Nature Communications, 2020
How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.
Likhitha Kolla, Michael C. Kelly, Zoe F. Mann, Alejandro Anaya-Rocha, Kathryn Ellis, Abigail Lemons, Adam T. Palermo, Kathy S. So, Joseph C. Mays, Joshua Orvis, Joseph C. Burns, Ronna Hertzano, Elizabeth C. Driver, Matthew W. Kelley   +13 more
doaj   +1 more source

Is the outcome of fitting hearing aids to adults affected by whether an audiogram-based prescription formula is individually applied? A systematic review protocol

BMJ Open, 2021
Introduction Hearing aids are typically programmed using the individual’s audiometric thresholds. Developments in technology have resulted in a new category of direct-to-consumer devices, which are not programmed using the individual’s audiometric ...
Kevin J Munro, Ibrahim Almufarrij, Harvey Dillon   +2 more
doaj   +1 more source

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

OncoImmunology, 2019
Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M.
Priya Patel, Lily Sun, Yvette Robbins, Paul E. Clavijo, Jay Friedman, Christopher Silvin, Carter Van Waes, John Cook, James Mitchell, Clint Allen   +9 more
doaj   +1 more source

Does probe-tube verification of real-ear hearing aid amplification characteristics improve outcomes in adult hearing aid users? A protocol for a systematic review

BMJ Open, 2020
Introduction Using a probe-tube microphone to measure and adjust the real-ear performance of the hearing aid to match the prescription target is recommended and widely used in clinical practice.
Kevin J Munro, Ibrahim Almufarrij, Harvey Dillon   +2 more
doaj   +1 more source

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Scientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu, Jin Woong Choi, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien   +6 more
doaj   +1 more source

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets

Frontiers in Molecular Neuroscience, 2021
The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP dysfunction for the purposes of transcriptional analysis and treatment ...
Ian A. Taukulis, Rafal T. Olszewski, Soumya Korrapati, Katharine A. Fernandez, Erich T. Boger, Tracy S. Fitzgerald, Robert J. Morell, Lisa L. Cunningham, Michael Hoa   +8 more
doaj   +1 more source

Seeing the Deaf in "Deafness" [PDF]

Journal of Deaf Studies and Deaf Education, 2008
This article draws on some of the existing literature on the politics of identity and representation as related to minority group formation. It applies this to constructions of Deaf2 identity from a cultural and linguistic perspective and contrasts this with dominant constructions of Deaf people as disabled. It highlights a number of ways in which Deaf
openaire   +2 more sources

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

OncoImmunology, 2018
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang, Clint T. Allen   +8 more
doaj   +1 more source

Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound [version 2; peer review: 2 approved, 1 not approved]

Wellcome Open Research, 2021
Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as ...
Dorothy V. M. Bishop, Clara R. Grabitz, Sophie C. Harte, Kate E. Watkins, Miho Sasaki, Eva Gutierrez-Sigut, Mairéad MacSweeney, Zoe V. J. Woodhead, Heather Payne   +8 more
doaj   +1 more source