Results 11 to 20 of about 247,945 (341)

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

open access: yesScientific Reports, 2021
Head and neck squamous cell carcinomas (HNSCC) induced by human papillomavirus (HPV) have increased recently in the US. However, the distinct alterations of molecules involved in the death pathways and drug effects targeting inhibitor of apoptosis ...
Yi An   +10 more
doaj   +1 more source

Disabilities in the Writing Center [PDF]

open access: yes, 2015
Since writing centers serve communities of teachers and learners, they will inevitably serve people with disabilities. Ever since the 1980s, writing center workers have explored the issue of tutoring students with disabilities, people who may require ...
Babcock, Rebecca Day
core   +1 more source

Seeing the Deaf in "Deafness" [PDF]

open access: yesJournal of Deaf Studies and Deaf Education, 2008
This article draws on some of the existing literature on the politics of identity and representation as related to minority group formation. It applies this to constructions of Deaf2 identity from a cultural and linguistic perspective and contrasts this with dominant constructions of Deaf people as disabled. It highlights a number of ways in which Deaf
openaire   +3 more sources

How level and type of deafness affects user perception of multimedia video clips [PDF]

open access: yes, 2003
Our research investigates the impact that hearing has on the perception of digital video clips, with and without captions, by discussing how hearing loss, captions and deafness type affects user QoP (Quality of Perception).
Ghinea, G, Gulliver, SR
core   +1 more source

Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

open access: yeseLife, 2020
Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of opposite hair bundle orientations. Previously, we showed that transcription factor Emx2, expressed in only one of the daughter HCs, generates this bidirectional HC ...
Sho Ohta   +3 more
doaj   +1 more source

Keratitis-ichthyosis-deafness syndrome, atypical connexin GJB2 genemutation, and peripheral T-cell lymphoma: more than a random association? [PDF]

open access: yes, 2011
Keratitis-ichthyosis-deafness (KID) syndrome is a rare congenital disorder characterized by a variety of skin lesions— that is, palmoplantar keratoderma, thickening of the skin, and erythematous verrucous lesions—neurosensorial hypoacusia, and keratitis
Contini, Salvatore   +6 more
core   +3 more sources

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

open access: yesOncoImmunology, 2018
Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from ...
Lillian Sun   +9 more
doaj   +1 more source

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct

open access: yesBMC Medical Genetics, 2019
Background Recessive mutations of coding regions and splice sites of the SLC26A4 gene cause hearing loss with enlargement of the vestibular aqueduct (EVA).
Janet R. Chao   +8 more
doaj   +1 more source

Behavioral models of tinnitus and hyperacusis in animals

open access: yesFrontiers in Neurology, 2014
The phantom perception of tinnitus and reduced sound level tolerance associated with hyperacusis, have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments.
Sarah H Hayes   +3 more
doaj   +1 more source

Characterization of the development of the mouse cochlear epithelium at the single cell level

open access: yesNature Communications, 2020
How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.
Likhitha Kolla   +13 more
doaj   +1 more source

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