Results 21 to 30 of about 365,870 (389)

Keratitis-ichthyosis-deafness syndrome, atypical connexin GJB2 genemutation, and peripheral T-cell lymphoma: more than a random association? [PDF]

open access: yes, 2011
Keratitis-ichthyosis-deafness (KID) syndrome is a rare congenital disorder characterized by a variety of skin lesions— that is, palmoplantar keratoderma, thickening of the skin, and erythematous verrucous lesions—neurosensorial hypoacusia, and keratitis
Contini, Salvatore   +6 more
core   +3 more sources

Characterization of the development of the mouse cochlear epithelium at the single cell level

open access: yesNature Communications, 2020
How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.
Likhitha Kolla   +13 more
doaj   +1 more source

Is the outcome of fitting hearing aids to adults affected by whether an audiogram-based prescription formula is individually applied? A systematic review protocol

open access: yesBMJ Open, 2021
Introduction Hearing aids are typically programmed using the individual’s audiometric thresholds. Developments in technology have resulted in a new category of direct-to-consumer devices, which are not programmed using the individual’s audiometric ...
Kevin J Munro   +2 more
doaj   +1 more source

Bone conductive implants in single sided deafness [PDF]

open access: yes, 2015
Conclusion: The Bone Conductive Implants (BCI) showed to partly restore some of the functions lost when the binaural hearing is missing, such as in the single-sided deafness (SSD) subjects.
ATTURO, FRANCESCA   +4 more
core   +1 more source

Does probe-tube verification of real-ear hearing aid amplification characteristics improve outcomes in adult hearing aid users? A protocol for a systematic review

open access: yesBMJ Open, 2020
Introduction Using a probe-tube microphone to measure and adjust the real-ear performance of the hearing aid to match the prescription target is recommended and widely used in clinical practice.
Kevin J Munro   +2 more
doaj   +1 more source

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

open access: yesOncoImmunology, 2019
Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M.
Priya Patel   +9 more
doaj   +1 more source

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

open access: yesScientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu   +6 more
doaj   +1 more source

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets

open access: yesFrontiers in Molecular Neuroscience, 2021
The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP dysfunction for the purposes of transcriptional analysis and treatment ...
Ian A. Taukulis   +8 more
doaj   +1 more source

Monaural Congenital Deafness Affects Aural Dominance and Degrades Binaural Processing

open access: yesCerebral Cortex, 2016
Cortical development extensively depends on sensory experience. Effects of congenital monaural and binaural deafness on cortical aural dominance and representation of binaural cues were investigated in the present study.
J. Tillein, P. Hubka, A. Kral
semanticscholar   +1 more source

Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound [version 2; peer review: 2 approved, 1 not approved]

open access: yesWellcome Open Research, 2021
Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as ...
Dorothy V. M. Bishop   +8 more
doaj   +1 more source

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