Results 41 to 50 of about 53,995 (223)
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
Synaptic mitochondria regulate hair-cell synapse size and function
eLife, 2019 Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are defined by electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ribeye.
Hiu-tung C Wong +5 more
doaj +1 more source
Hearing through Vibrations: Perception of Musical Emotions by Profoundly Deaf People [PDF]
arXiv, 2020 Advances in tactile-audio feedback technology have created new possibilities for deaf people to feel music. However, little is known about deaf individuals' perception of musical emotions through vibrotactile feedback. In this paper, we present the findings from a mixed-methods study with 16 profoundly deaf participants. The study protocol was designed
arxiv
Advanced Science, EarlyView.In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa +6 more
wiley +1 more source
Cisplatin is retained in the cochlea indefinitely following chemotherapy
Nature Communications, 2017 Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.
Andrew M. Breglio +8 more
doaj +1 more source
eLife, 2020 Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle, comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the base of the kinocilium and the stereocilia develop adjacent to it ...
Yosuke Tona, Doris K Wu
doaj +1 more source
Deaf, Hard of Hearing, and Hearing Perspectives on using Automatic Speech Recognition in Conversation [PDF]
, 2019 Many personal devices have transitioned from visual-controlled interfaces to speech-controlled interfaces to reduce costs and interactive friction, supported by the rapid growth in capabilities of speech-controlled interfaces, e.g., Amazon Echo or Apple's Siri.
arxiv +1 more source
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Current Challenges in Efficient Lithium‐Ion Batteries’ Recycling: A Perspective
Global Challenges, Volume 6, Issue 12, December 2022., 2022 Rapid prospering of the electric vehicle industries makes Li‐ion batteries (LIBs) recycling an urgent need. However, the global LIB recycling effort is hampered by various challenges, including recycling/upcycling techniques, global government policies, and economic and environmental implications.
Xiaolu Yu +6 more
wiley +1 more source
Deafness gene screening based on a multilevel cascaded BPNN model
BMC Bioinformatics, 2023 Sudden sensorineural hearing loss is a common and frequently occurring condition in otolaryngology. Existing studies have shown that sudden sensorineural hearing loss is closely associated with mutations in genes for inherited deafness. To identify these
Xiao Liu +5 more
doaj +1 more source