Results 51 to 60 of about 53,995 (223)

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

The impact of face coverings on audio-visual contributions to communication with conversational speech

Cognitive Research
The use of face coverings can make communication more difficult by removing access to visual cues as well as affecting the physical transmission of speech sounds.
I. R. Jackson, E. Perugia, M. A. Stone, G. H. Saunders   +3 more
doaj   +1 more source

Indian Sign Language Recognition Using Mediapipe Holistic [PDF]

arXiv, 2023
Deaf individuals confront significant communication obstacles on a daily basis. Their inability to hear makes it difficult for them to communicate with those who do not understand sign language. Moreover, it presents difficulties in educational, occupational, and social contexts.
arxiv  

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view

Human Brain Mapping, Volume 44, Issue 1, Page 170-185, January 2023., 2023
In this manuscript, we develop a method utilizing the distribution of resting‐state fMRI connectivity measurements to study the effect of a direct stimulation. The method can drastically reduce the number of multiple comparisons compared with edge‐wise analysis.
Bohao Tang, Yi Zhao, Archana Venkataraman, Kyrana Tsapkini, Martin A. Lindquist, James Pekar, Brian Caffo   +6 more
wiley   +1 more source

SWift -- A SignWriting improved fast transcriber [PDF]

Proceedings of the International Working Conference on Advanced Visual Interfaces, ACM - Association for Computer Machinery, pp.390 - 393, 2012, ACM AVI2012, 978-1-4503-1287-5, 2019
We present SWift (SignWriting improved fast transcriber), an advanced editor for computer-aided writing and transcribing using SignWriting (SW). SW is devised to allow deaf people and linguists alike to exploit an easy-to-grasp written form of (any) sign language.
arxiv   +1 more source

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Biallelic pathogenic variants in COX11 are associated with an infantile‐onset mitochondrial encephalopathy

Human Mutation, Volume 43, Issue 12, Page 1970-1978, December 2022., 2022
Abstract Primary mitochondrial diseases are a group of genetically and clinically heterogeneous disorders resulting from oxidative phosphorylation (OXPHOS) defects. COX11 encodes a copper chaperone that participates in the assembly of complex IV and has not been previously linked to human disease. In a previous study, we identified that COX11 knockdown
Rocio Rius, Neal K. Bennett, Kaustuv Bhattacharya, Lisa G. Riley, Zafer Yüksel, Luke E. Formosa, Alison G. Compton, Russell C. Dale, Mark J. Cowley, Velimir Gayevskiy, Saeed M. Al Tala, Abdulrahman A. Almehery, Michael T. Ryan, David R. Thorburn, Ken Nakamura, John Christodoulou   +15 more
wiley   +1 more source

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

Neoplasia: An International Journal for Oncology Research, 2014
Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that
Hai Lu, Carol Yan, Xin Xin Quan, Xinping Yang, Jialing Zhang, Yansong Bian, Zhong Chen, Carter Van Waes   +7 more
doaj   +1 more source