Results 51 to 60 of about 145,362 (297)

Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2

eLife, 2020
Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle, comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the base of the kinocilium and the stereocilia develop adjacent to it ...
Yosuke Tona, Doris K Wu
doaj   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

Annals of Neurology, EarlyView.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles, Caroline Nelson, Ivan Ayala, Elena Barbieri, Rudolph Castellani, Changiz Geula, Tamar Gefen, M. Marsel Mesulam   +7 more
wiley   +1 more source

Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma

Scientific Reports
Immune checkpoint blockade (ICB) is a commonly used treatment modality for cancer with a growing list of oncologic indications. Ototoxicity is a potential immune-related adverse event of ICB treatment, but the risk of hearing loss after ICB remains ...
Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez   +11 more
doaj   +1 more source

Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis

Frontiers in Molecular Neuroscience, 2019
The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell mechanotransduction and hearing.
Soumya Korrapati, Ian Taukulis, Rafal Olszewski, Madeline Pyle, Shoujun Gu, Riya Singh, Carla Griffiths, Daniel Martin, Erich Boger, Robert J. Morell, Michael Hoa   +10 more
doaj   +1 more source

An Examination of Racial Bias in Scoring the Autism Diagnostic Observation Schedule (ADOS) Module 3: An Item Response Theory Analysis

Autism Research, EarlyView.
ABSTRACT Given the rising prevalence of autism among racial minority children in the United States, but persistent service use disparities, this study examines potential bias in specific items from the autism diagnostic observation schedule (ADOS), a highly regarded autism evaluation.
Yuen Yvonne Yu, Austin Wyman, Calliana J. Faulk, Lizzy J. Fulop, Rebecca L. Greenberg, Rachel M. Benecke, Lauren K. Steinbeck, Jessica Foy, Caitlyn Kim, George O. Emory, Eric A. Storch, Casey J. Zampella, Benjamin E. Yerys, Robert T. Schultz, Julia Parish‐Morris, John D. Herrington, Caitlin C. Clements   +16 more
wiley   +1 more source

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Cell Reports, 2015
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET ...
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar   +14 more
doaj   +1 more source

Measurement Invariance of the PROMIS Family Relationships Scale Among Autistic and General Population Adolescents

Autism Research, EarlyView.
ABSTRACT Social relationships are a key component of quality of life, a high‐priority outcome for autistic people, and family relationships are critical in adolescence. The PROMIS Family Relationships scale has been well validated for use with the general population, but psychometric validation in the autistic population is lacking.
Rachel M. Benecke, Zachary J. Williams, Laura Graham Holmes, Judith S. Miller, Elizabeth A. Kaplan‐Kahn   +4 more
wiley   +1 more source

The acoustic change complex as a diagnostic tool for cochlear dead regions evaluated in normally hearing adults

Scientific Reports
The loss of inner hair cells and/or neurons in the cochlea leads to cochlear dead regions (DRs). One of the consequences of DRs is noisy transmission of information from the cochlea to the brain, which results in poorer than expected perception of speech
Anna Schelenz, Emanuele Perugia, Lin Wu, Ewa Skrodzka, Karolina Kluk   +4 more
doaj   +1 more source

Clinical efficacy of mepolizumab and dupilumab for eosinophilic otitis media: Analysis of patient clinical characteristic

Allergology International
Background: Eosinophilic otitis media (EOM) is characterized by eosinophilic infiltration of the middle ear; it is frequently associated with bronchial asthma and chronic rhinosinusitis with nasal polyposis. Although biologics have been used to treat EOM,
Saori Kikuchi, Tomonori Sugiyama, Saemi Suzuki, Yukiko Iino   +3 more
doaj   +1 more source