Results 91 to 100 of about 18,296 (185)

Quantitative Multiplexed Rapid Immunoprecipitation and Mass Spectrometry of Endogenous Proteins (qPLEX‐RIME) in Cell Lines

Current Protocols, Volume 6, Issue 11, November 2026.
Abstract Quantitative multiPLEXed Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins (qPLEX‐RIME) is a method for the quantitative discovery of endogenous protein complexes, without the need for genetically encoded affinity tags. It is particularly well suited to chromatin‐associated proteins and transcription factors, permitting ...
Soleilmane Omarjee, Evangelia K. Papachristou, Chandra Sekhar Reddy Chilamakuri, Hamish McMillan, Kamal Kishore, Joshua Kent, Valar Nila Roamio Franklin, Clive D'Santos, Jason S. Carroll   +8 more
wiley   +1 more source

Phosphate-Catalyzed Succinimide Formation from an NGR-Containing Cyclic Peptide: A Novel Mechanism for Deammoniation of the Tetrahedral Intermediate

Molecules, 2018
Spontaneous deamidation in the Asn-Gly-Arg (NGR) motif that yields an isoAsp-Gly-Arg (isoDGR) sequence has recently attracted considerable attention because of the possibility of application to dual tumor targeting.
Ryota Kirikoshi, Noriyoshi Manabe, Ohgi Takahashi   +2 more
doaj   +1 more source

Modeling deamidation in sheep α-keratin peptides and application to archeological wool textiles

, 2014
Deamidation of glutamine (Q) and asparagine (N) has been recognized as a marker of degradation and aging in ancient proteins. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) to study deamidation in wool ...
Peacock, Elizabeth E., Dyer, Jolon M, Dyer, Jolon M., Walton Rogers, Penelope, Collins, Matthew J, Wilson, Julie, Plowman, Jeffrey E., Clerens, Stefan, Plowman, Jeffrey Ernest, Collins, Matthew J., Von Holstein, Isabella; id_orcid, Solazzo, Caroline, Peacock, Elizabeth Ellen,, von Holstein, Isabella   +13 more
core   +1 more source

Effect of Cold Plasma and Plasma Activated Water on Polyphenols, Vitamins, and Volatile Compounds in Fresh‐Cut Carrots

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Synthesis of the results of polyphenols, vitamins, and volatile compounds in fresh‐cut carrots treated with CP and PAW. ABSTRACT This study aimed to evaluate content of bioactive compounds (polyphenols and vitamins B2 and B3 by HPLC‐MS/MS and spectrophotometric analysis, ascorbic acid by HPLC‐DAD and the volatile profile by HS‐SPME‐GC–MS) in fresh‐cut ...
L. Acquaticci, E. Torregiani, J. B. Molina Hernandez, G. G. Gebremical, S. Tappi, G. Caprioli   +5 more
wiley   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Bacterial sialidases subvert the complement system through desialylation

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Bacterial sialidases (neuraminidases) are widely studied virulence factors, yet their impact on the complement system, a central component of innate immunity, remains poorly understood. Here, we investigate the effects of six sialidases from five human pathogens, including Bacteroides fragilis, Clostridium perfringens, Tannerella forsythia ...
Kurni Kurniyati, Nicholas D. Clark, Qin Fu, Sheng Zhang, Weigang Qiu, Michael G. Malkowski, Chunhao Li   +6 more
wiley   +1 more source

Deamidation of collagen

, 2012
Collagen is the major component of skin, tendons, ligaments, teeth, and bones, it provides the framework that holds most multicellular animals together, and collagen type I constitutes the major fibrillar collagen of bone.
O’Connor, Peter B., Perez Hurtado, Pilar   +1 more
core   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, Volume 22, Issue 62, 6 November 2026.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Development of celiac-safe foods: prevention of transglutaminase 2 (TG2) deamidation of gluten in healthy non-celiac volunteers

Frontiers in Nutrition
In celiac disease, intestinal transglutaminase (TG2) produces immunogenic peptides by deamidation of gluten proteins. These products drive the celiac immune response. We have previously identified an interaction between gliadin and a food additive, E304i,
Niklas Engström, Niklas Engström, Lena Böhn, Lena Böhn, Axel Josefsson, Stine Störsrud, Nathalie Scheers   +6 more
doaj   +1 more source