ABSTRACT Background Haemophilia is a chronic, lifelong bleeding disorder that requires interdisciplinary care to manage and mitigate the disease burden throughout a patient's life. There is no universally accepted protocol for managing haemophilia patients during dental care.
Mathangi Kumar+6 more
wiley +1 more source
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta‐analysis [PDF]
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the relative efficacy of pharmacological interventions for preventing blood loss in elective primary or revision hip or knee replacement, and to identify
Champaneria, R+4 more
core +2 more sources
ABSTRACT We describe the successful treatment of biliary duct obstruction (BDO) secondary to biliary carcinoma involving the bile duct, cystic duct, and intrahepatic ducts in two adult domestic shorthair cats using a novel technique. Both cats presented with marked hyperbilirubinemia, increased liver enzyme activities, and ultrasonographic evidence of ...
Robin Doherty+2 more
wiley +1 more source
Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass? [PDF]
It has been suggested that desmopressin acetate (DDAVP) administration reduces blood loss after cardiac surgery. We have investigated the effect of DDAVP administration in a double-blind, randomized, prospective trial including 100 patients placed on ...
Arcas, R. (R.)+5 more
core +1 more source
Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi+6 more
wiley +1 more source
JUSTIFICATIVA E OBJETIVOS: Os pacientes portadores da doença de von Willebrand apresentam sangramento anormal após ferimentos e procedimentos cirúrgicos, já que esta afeta a hemostasia primária e secundária devido à alteração do fator VIII.
Roberto Martins Matos Junior+4 more
doaj +1 more source
Randomized study of aprotinin and DDAVP to reduce postoperative bleeding after cardiopulmonary bypass surgery [PDF]
BACKGROUND: Patients on cardiopulmonary bypass (CPB) have an increased susceptibility to postoperative bleeding. Previous reports using desmopressin acetate (DDAVP) for the prevention of postoperative bleeding have given contradictory results, whereas ...
Arroyo, J.L. (José L.)+5 more
core +1 more source
Acute Compartment Syndrome in Congenital and Acquired Haemophilia
ABSTRACT Background Acute compartment syndrome (ACS) is a surgical emergency defined as an increase in intramuscular pressure within a compartment that compromises capillary perfusion and threatens the survival of compartment tissues. A sustained increase in compartment pressure causes irreversible necrosis of nerves and muscles, leading to permanent ...
Emerito Carlos Rodriguez‐Merchan+2 more
wiley +1 more source
A phase II dose-escalation trial of perioperative desmopressin (1-desamino-8-d-arginine vasopressin) in breast cancer patients [PDF]
Desmopressin (dDAVP) is a well-known peptide analog of the antidiuretic hormone vasopressin, used to prevent excessive bleeding during surgical procedures. dDAVP increases hemostatic mediators, such as the von Willebrand factor (vWF), recently considered
Alonso, Daniel Fernando+21 more
core +4 more sources
Association of Anaesthetists guidelines: the use of blood components and their alternatives
Summary Background The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri‐operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and ...
Akshay Shah+12 more
wiley +1 more source