Results 251 to 260 of about 12,734,425 (305)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

c-Jun N-Terminal Kinase: A Spatiotemporal Regulator of Cell Fate and Function. [PDF]

Biology (Basel)
Thesing S, Salahuddin M, Okonek E, Hanson RL.   +3 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection. [PDF]

MedComm (2020)
Wang Q, Zhou Y, Ding T, Sun Y, Yang Y, Wu Y, Liu J, Lu S, Yang J.   +8 more
europepmc   +1 more source

Extracellular Signal-Regulated Kinase and Reactive Oxygen Species Regulate PD-L1 to Promote Migration and Proliferation of Triple-Negative Breast Cancer MDA-MB-231 Cells. [PDF]

Oncol Res
Ho CC, Chen YC, Lean WL, Wu WS.
europepmc   +1 more source

Blood-based kinase activity profiling to predict response to immune checkpoint inhibitors in patients with advanced stage NSCLC: the prospective IOpener study. [PDF]

J Immunother Cancer
de Joode K, Groen HJ, Heuvel MVD, Kloover JS, Van Der Meer F, Van der Leest CH, Van Den Borne B, De Wijn R, Hurkmans DP, Van den Heuvel DMA, Pinedo HM, Kapiteijn E, Debets R, Verdegaal EME, Van der Burg SH, Groten JP, Aerts JGJV, Mathijssen RHJ.   +17 more
europepmc   +1 more source

Melatonin Protects BEAS-2B Cells Against Hypoxia/Reoxygenation-Induced Injury By Reducing MLKL Levels, Suppressing Oxidative Stress and Preserving Mitochondrial Function. [PDF]

Cell Biochem Funct
Yilmaz Z, Tas A, Oz O, Koyuncu I, Temiz E, Yuksekdag O.   +5 more
europepmc   +1 more source

The cross-talk between GSK-3β, RKIP, and PTEN as potential targets for therapeutic implications in cancer: a comprehensive insight. [PDF]

J Pharm Pharm Sci
Mosalam EM, Abdallah MS, Gardouh AR, Hamza E, Bahaa MM, Nazih M, Al-Dhelaan RA, Kamal N.   +7 more
europepmc   +1 more source

Autophagy-Apoptosis Crosstalk in Cancer: Mechanisms, Signaling Pathways, and Therapeutic Targeting. [PDF]

Cancers (Basel)
Kakkar D, Saxena S, Dhawan U, Dosi N, Khanna C, Paul S.   +5 more
europepmc   +1 more source