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The Death-Associated Protein Kinases: Structure, Function, and Beyond
Annual Review of Biochemistry, 2006Death-associated protein kinase (DAPk) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death–associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has ...
Adi Kimchi, Shani Bialik
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Death‐associated protein kinases and intestinal epithelial homeostasis
The Anatomical Record, 2022AbstractThe family of death‐associated protein kinases (DAPKs) and DAPK‐related apoptosis‐inducing protein kinases (DRAKs) act as molecular switches for a multitude of cellular processes, including apoptotic and autophagic cell death events.
Huey‐Miin Chen, Justin A. MacDonald
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Death associated protein kinase as a potential therapeutic target
Expert Opinion on Therapeutic Targets, 2002Death associated protein kinase (DAPK) is a calmodulin (CaM)-regulated serine/threonine protein kinase implicated in diverse apoptosis pathways, including those involved in neuronal cell death and tumour suppression. The requirement of DAPK catalytic activity for its proposed cell functions and the validation of protein kinases as therapeutic targets ...
Andrew M, Schumacher +2 more
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Methylation of death-associated protein kinase in ovarian carcinomas
International Journal of Gynecological Cancer, 2006Death-associated protein (DAP) kinase is a serine/threonine kinase that plays an integral role in apoptosis and metastasis. The purpose of our study was to determine the methylation status of DAP kinase in ovarian carcinomas. Thirty-one patients with histologically confirmed epithelial ovarian cancers treated at Roswell Park Cancer Institute, Buffalo ...
Y, Collins +4 more
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Structure and enzymology of a death-associated protein kinase
Trends in Pharmacological Sciences, 2002The structure of the catalytic domain of death-associated protein kinase (DAPK), a serine/threonine kinase implicated in programmed cell death and tumor suppression, has been determined recently in several crystal forms, including the highest resolution kinase structure available.
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Death‐associated protein kinase expression in human temporal lobe epilepsy
Annals of Neurology, 2004AbstractExperimental and human data suggest programmed (active) cell death may contribute to the progressive hippocampal atrophy seen in patients with refractory temporal lobe epilepsy. Death‐associated protein (DAP) kinase is a novel calcium/calmodulin‐activated kinase that functions in apoptosis mediated by death receptors.
David C, Henshall +5 more
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