Results 111 to 120 of about 2,980,721 (284)

Scarred by a death receptor [PDF]

The Journal of Cell Biology, 2007
![Graphic][1] The fibrin (red) that blocks nerve healing is degraded when p75NTR isn't around (right) to dampen tPA levels. Even when it's not killing, a death receptor still finds ways to inflict damage. On page [1119][2], Sachs et al.
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification [PDF]

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
core   +1 more source

PTPN23-dependent ESCRT machinery functions as a cell death checkpoint

Nature Communications
Cell death plasticity is crucial for modulating tissue homeostasis and immune responses, but our understanding of the molecular components that regulate cell death pathways to determine cell fate remains limited.
Dongyan Song, Yuxin Cen, Zhe Qian, Xiaoli S. Wu, Keith Rivera, Tse-Luen Wee, Osama E. Demerdash, Kenneth Chang, Darryl Pappin, Christopher R. Vakoc, Nicholas K. Tonks   +10 more
doaj   +1 more source

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Frontiers in Immunology, 2018
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular ...
Gustavo P. Amarante-Mendes, Gustavo P. Amarante-Mendes, Sandy Adjemian, Sandy Adjemian, Laura Migliari Branco, Laura Migliari Branco, Larissa C. Zanetti, Ricardo Weinlich, Karina R. Bortoluci, Karina R. Bortoluci   +9 more
doaj   +1 more source

HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. [PDF]

PLoS Pathog, 2023
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, Welbon C, James CD, Morgan IM, Spanos WC, Pyeon D.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors. [PDF]

Cells, 2023
Anzovino A, Canepa E, Alves M, Lemon NL, Carare RO, Fossati S.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Recombinant glycine receptors: stoichiometry and kinetics [PDF]

, 2009
Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
core