Results 111 to 120 of about 588,475 (248)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Expression of inhibitory receptors on CD4+ and CD8+ T cells from healthy Colombian donors
Universitas Scientiarum, 2012 T cell activation involves positive cellular signals that promote effector functions and negative signals that contribute to the regulationof these responses.
Adriana Cuéllar, Paola Lasso
doaj
Death Receptors and Their Ligands in Inflammatory Disease and Cancer. [PDF]
Cold Spring Harb Perspect Biol, 2020 Annibaldi A, Walczak H.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Glycans on death receptors as sweet markers and signaling checkpoints
Frontiers in Cell DeathApoptosis is a form of programmed cell death that eliminates excessive and damaged cells. It can be conducted by two ways: the extrinsic and the intrinsic (mitochondrial) pathways.
Kamil Seyrek +4 more
doaj +1 more source
Macrophage-like THP-1 Cells Derived from High-Density Cell Culture Are Resistant to TRAIL-Induced Cell Death via Down-Regulation of Death-Receptors DR4 and DR5. [PDF]
Biomolecules, 2022 Lomovskaya YV +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder. [PDF]
Mol Psychiatry, 2021 Liu W, Vetreno RP, Crews FT.
europepmc +1 more source