Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells [PDF]
Epigenetics, 2021 Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumour cells is one of the major reasons for drug resistance, but ...
Anup Kumar Singh +11 more
doaj +3 more sources
TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors [PDF]
Drug Delivery, 2017 Active targeting nanoparticles were developed to simultaneously codeliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Curcumin (Cur).
Xi Yang +5 more
doaj +3 more sources
Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors [PDF]
Cells, 2020 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has attracted attention as a potential candidate for cancer therapy. However, many primary cancers are resistant to TRAIL, even when combined with standard chemotherapy.
Won Hyeok Lee +8 more
doaj +2 more sources
Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL [PDF]
Frontiers in Cell and Developmental Biology, 2021 Tumor necrosis factor-associated ligand inducing apoptosis (TRAIL) induces apoptosis through the death receptors (DRs) 4 and 5 expressed on the cell surface. Upon ligand stimulation, death receptors are rapidly internalized through clathrin-dependent and
Artem A. Artykov +8 more
doaj +2 more sources
Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2019 In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Valery Leytin PhD +2 more
doaj +2 more sources
The Association of Death Receptors and TGF-β1 Expression in Urothelial Bladder Cancer and Their Prognostic Significance [PDF]
BiomedicinesDeath receptor signalization that triggers the extrinsic apoptotic pathway and TGF-β1 have important roles in urothelial carcinogenesis, with a complex interplay between them. The aim of this research was to assess the association of death receptors DR4,
Slavica Stojnev +6 more
doaj +2 more sources
Death receptors as targets in cancer. [PDF]
Br J Pharmacol, 2013 Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or TRAIL‐R2, have been disappointing so far, despite clear evidence of clinical activity and lack of adverse events for the vast majority of these compounds, whether combined or not ...
Micheau O, Shirley S, Dufour F.
europepmc +5 more sources
An introduction to death receptors in apoptosis
International Journal of Surgery, 2005 Apoptosis is a source of much research interest across many fields, including developmental biology, immunology and oncology. As the exact pathways of this process are identified, so too are potential avenues for therapeutic application. Death receptors are important in inducing apoptosis and together with their ligands have become a source of ...
A N Warrens
exaly +3 more sources
Editorial: Death Receptors, Non-apoptotic Signaling Pathways and Inflammation [PDF]
Frontiers in Immunology, 2020 Eva Szegezdi, Patrick Legembre
doaj +2 more sources
Apoptosis signaling by death receptors
European Journal of Biochemistry, 1998 Death receptors have been recently identified as a subgroup of the TNF‐receptor superfamily with a predominant function in induction of apoptosis. The receptors are characterized by an intracellular region, called the death domain, which is required for the transmission of the cytotoxic signal.
Schulze-Osthoff, Klaus +4 more
openaire +6 more sources