Results 31 to 40 of about 3,277,607 (280)
Death receptor signals to the mitochondria [PDF]
Cancer Biology & Therapy, 2004 Apoptosis is the best-characterized form of programmed cell death (PCD) and is of fundamental importance in tissue homeostasis. In mammalian systems, there are two major pathways that are involved in the initiation of apoptosis: the "extrinsic" death receptor pathway and the "intrinsic" mitochondrial pathway.
Khosravi-Far, Roya, Esposti, Mauro Degli
openaire +2 more sources
Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death
Frontiers in Bioscience-Scholar, 2021 TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy.
Fatma Guesmi +7 more
doaj +1 more source
eLife, 2021 Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis.
Joshua D Greenlee +6 more
doaj +1 more source
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) knockout (KO) cells were generated to investigate the role of TRAF2 in signaling by TNFR1 and the CD95-type death receptors (DRs) TRAILR1/2 and CD95.
Jennifer Kreckel +4 more
doaj +1 more source
Life and death by death receptors
The FASEB Journal, 2009 ABSTRACT Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the “death domain” that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation and recruitment of
Maria Eugenia, Guicciardi +1 more
openaire +3 more sources
Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines [PDF]
, 2009 Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane +11 more
core +1 more source
Frontiers in Pharmacology, 2022 GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system. One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state which ...
Musadiq A. Bhat +6 more
doaj +1 more source
Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. [PDF]
, 2012 Thus, we evaluated the immunofluorescence pattern of TRAIL-receptors and E-cadherin to assess the fraction of membrane-bound TRAIL-receptors in 231 selected patients with early-stage CRC undergoing surgical treatment only.
Göke, Burkhard +32 more
core +2 more sources
A DR4, DR5 Targeting Conjugated TRAIL Treatment for Colorectal Carcinogenesis: A Way to Future? [PDF]
Pharmaceutical SciencesTRAIL or tumor necrosis factor-related apoptosis-inducing ligand has been one of the major frontiers for the chemotherapeutic approach to treating carcinogenesis.
Parikshit Roychowdhury +7 more
doaj +1 more source
Frontiers in Immunology, 2021 Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire +7 more
doaj +1 more source