Results 101 to 110 of about 813,296 (157)

Control of mRNA decapping by autoinhibition

, 2018
5’ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are understood, the role of abundant intrinsically disordered regions (IDRs) is lacking.
Tibble, Ryan W, Daifuku, Tristan S, Gross, John D, John D Gross, David R Paquette, Ryan W Tibble, Paquette, David R, Tristan S Daifuku   +7 more
core   +1 more source

The Seneca Valley virus 3C protease cleaves DCP1A to attenuate its antiviral effects

Veterinary Research
Seneca Valley virus (SVV), a new member of Picornaviridae, causes idiopathic vesicular symptoms in pregnant sows and acute death in neonatal piglets, considerably damaging the swine industry.
Jingjing Yang, Zijian Li, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Xuexia Wen, Jiangwei Song   +7 more
doaj   +1 more source

HPat provides a link between deadenylation and decapping in metazoa

, 2010
Decapping of eukaryotic messenger RNAs (mRNAs) occurs after they have undergone deadenylation, but how these processes are coordinated is poorly understood.
Elisa Izaurralde, Izaurralde, E., Braun, J., Gabrielle Haas, Igreja, C., Haas, G., Tritschler, F., Joerg E. Braun, Nishihara, T., Cátia Igreja, Felix Tritschler, Tadashi Nishihara   +11 more
core   +1 more source

Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. [PDF]

Cell Chem Biol, 2021
Luo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA.   +5 more
europepmc   +1 more source

Biochemical analysis of the mRNA scavenger decapping enzymes

, 2007
The modulation of mRNA degradation is an essential determining point for regulation of gene expression. Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNAs.
Liu, Shin-Wu
core   +1 more source

Biochemical analysis of human eIF4E-DCP2 interaction: Implications for the relationship between translation initiation and decapping.

PLoS ONE
All eukaryotic mRNAs bear a 7-methylguanosine cap on their 5' end. The 5' cap enables mRNA translation by binding directly to eIF4E; which further recruits other factors and the 40S ribosome.
Zachary F Mandell, Jeff Coller
doaj   +1 more source

Structural and functional studies of the Scavenger Decapping Enzyme DcpS: Untersuchungen zur Struktur und Funktion des Scavenger Decapping Enzyms DcpS

, 2019
Messenger RNA (mRNA) is the working copy of a gene containing the information for the production of a specific protein. The amount of any given protein has to be adjusted to the current needs of a cell.
Fuchs, A. ; https://orcid.org/
core   +1 more source

Regulation of mammalian mRNA decapping

, 2011
The modulation of mRNA degradation plays a critical role for regulation of gene expression. A major mRNA decay pathway in mammals proceeding from the 5' to 3' end is initiated with shortening of 3' poly (A) tail, followed by the cleavage of the 5' cap ...
Li, You
core   +1 more source

Liquid–liquid phase separation and the formation of amyloid fibrils from DcpS scavenger enzymes

Scientific Reports
Decapping Scavenger (DcpS) enzyme was initially identified by its ability to hydrolyze the cap structure resulting from mRNA decay. Human DcpS is an established target for acute myeloid leukemia (AML) and hepatic metastasis.
Aleksandra Ferenc-Mrozek, Maria Winiewska-Szajewska, Hanna Nieznańska, Anna Anielska-Mazur, Marek Warzecha, Wojciech Dzwolak, Maciej Łukaszewicz   +6 more
doaj   +1 more source

mRNA decapping enzyme2 DCP2 expression correlates with progression and prognosis of hepatocellular carcinoma

Scientific Reports
mRNA decapping enzyme 2 (DCP2) is a key regulator of mRNA degradation, influencing RNA metabolism and gene expression. While implicated in various diseases, its role in Hepatocellular carcinoma (HCC) remains unclear.
Tianyi Huang, Rui Wang, Cuihua Lu, Jiaying Zhang   +3 more
doaj   +1 more source