Results 91 to 100 of about 813,296 (157)

Lumpy skin disease virus LSDV087 positively regulates innate immune response by promoting oligomerization of MITA/STING

Journal of Virology
Lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), is a contagious disease in cattle that poses a major threat to the global cattle industry.
Zhen-Zhen Li, Yu-Lin Yang, Meng-Yao Sun, Hong-Bing Shu, Li-Bo Cao   +4 more
doaj   +1 more source

The mouse Balbiani body regulates primary oocyte quiescence via RNA storage

Communications Biology
In mammalian females, the transition from dormancy in primordial follicles to follicular development is critical for maintaining ovarian function and reproductive longevity.
Lei Lei, Kanako Ikami, Edgar Andres Diaz Miranda, Sooah Ko, Faith Wilson, Haley Abbott, Ronald Pandoy, Shiying Jin   +7 more
doaj   +1 more source

Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC. [PDF]

ACS Chem Biol, 2022
Swartzel JC, Bond MJ, Pintado-Urbanc AP, Daftary M, Krone MW, Douglas T, Carder EJ, Zimmer JT, Maeda T, Simon MD, Crews CM.   +10 more
europepmc   +1 more source

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2) [PDF]

, 2008
The Arabidopsis thaliana decapping enzyme (AtDcp2) was characterized by bioinformatics analysis and by biochemical studies of the enzyme and mutants produced by recombinant expression.
Gunawardana, D, Cheng, HC, Gayler, KR
core   +1 more source

Structure and Function in Homodimeric Enzymes: Simulations of Cooperative and Independent Functional Motions.

PLoS ONE, 2015
Large-scale conformational change is a common feature in the catalytic cycles of enzymes. Many enzymes function as homodimers with active sites that contain elements from both chains.
Stephen A Wells, Marc W van der Kamp, John D McGeagh, Adrian J Mulholland   +3 more
doaj   +1 more source

Judge, Jury, and Executioner: DXO Functions as a Decapping Enzyme and Exoribonuclease in Pre-mRNA Quality Control [PDF]

, 2013
In this issue of Molecular Cell, Jiao et al. (2013) describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping, and 5'-3' exoribonuclease activity and functions as an important checkpoint in cotranscriptional capping of RNA polymerase ...
Gross, John D, Mugridge, Jeffrey S
core   +1 more source

Structural Insight into Molecular Inhibitory Mechanism of InsP₆ on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp. [PDF]

J Virol, 2022
Yang Y, Zhang C, Li X, Li L, Chen Y, Yang X, Zhao Y, Chen C, Wang W, Zhong Z, Yang C, Huang Z, Su D.   +12 more
europepmc   +1 more source

Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

Nature Communications
The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse organisms. TIR domain-containing proteins present in all kingdoms of life act in defense responses and can have NADase activity that hydrolyzes NAD+.
Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, Xuemei Chen   +8 more
doaj   +1 more source

Spontaneous and Targeted Mutations in the Decapping Enzyme Enhance Replication of Modified Vaccinia Virus Ankara (MVA) in Monkey Cells. [PDF]

J Virol, 2021
Erez N, Wyatt LS, Americo JL, Xiao W, Moss B.   +4 more
europepmc   +1 more source

Differential utilization of decapping enzymes in mammalian mRNA decay pathways

, 2011
mRNA decapping is a crucial step in the regulation of mRNA stability and gene expression. Dcp2 is an mRNA decapping enzyme that has been widely studied. We recently reported the presence of a second mammalian cytoplasmic decapping enzyme, Nudt16. Here we
Mangen Song, Megerditch Kiledjian, You Li   +2 more
core   +1 more source