Results 71 to 80 of about 813,296 (157)

Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

PLoS Genetics, 2018
Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping enzyme, and also associates with ...
Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, Alan G Hinnebusch   +5 more
doaj   +1 more source

Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources.

PLoS ONE, 2021
Pbp1, the yeast ortholog of human Ataxin-2, was originally isolated as a poly(A) binding protein (Pab1)-binding protein. Pbp1 regulates the Pan2-Pan3 deadenylase complex, thereby modulating the mRNA stability and translation efficiency.
Dang Thi Tuong Vi, Shiori Fujii, Arvin Lapiz Valderrama, Ayaka Ito, Eri Matsuura, Ayaka Nishihata, Kaoru Irie, Yasuyuki Suda, Tomoaki Mizuno, Kenji Irie   +9 more
doaj   +1 more source

Arabidopsis DXO1‐ and RNMT1‐Mediated m7G Capping of mRNA Modulates ABA Response

Plant, Cell &Environment, Volume 49, Issue 8, Page 5358-5372, August 2026.
ABSTRACT Eukaryotic mRNA carries an N7‐methylguanosine (m⁷G) 5′ cap that is essential for mRNA stability and function. Although traditionally viewed as a constitutive process, m⁷G capping is increasingly recognized as dynamically regulated to control gene expression in response to environmental stimuli.
Shumin Liang, Shangwei Wu, Chen Xiao, Hailei Zhang, Wuzhen Liu, Kefan Hu, Huijuan Tan, Hongwei Guo, Liming Xiong, Jiansheng Liang, Yiji Xia   +10 more
wiley   +1 more source

Mille viae in eukaryotic mRNA decapping

, 2017
Cellular mRNA levels are regulated via rates of transcription and decay. Since the removal of the mRNA 5'-cap by the decapping enzyme DCP2 is generally an irreversible step towards decay, it requires regulation.
Oliver Weichenrieder, Eugene Valkov, Jonas, S., Stefanie Jonas, Valkov, E., Weichenrieder, O.   +5 more
core   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Yeast Sm-like proteins function in mRNA decapping and decay [PDF]

, 2000
One of the main mechanisms of messenger RNA degradation in eukaryotes occurs by deadenylation-dependent decapping which leads to 5'-to-3' decay1, 2. A family of Sm-like (Lsm) proteins has been identified, members of which contain the 'Sm' sequence motif,
Tharun, Sundaresan, Andrew E. Mayes, Roy Parker, Mayes, Andrew E., Jean D. Beggs, Lennertz, Pascal, Beggs, Jean D, Sundaresan Tharun, Pascal Lennertz, Weihai He, Parker, Roy, He, Weihai   +11 more
core   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

Application of Mammalian Nudix Enzymes to Capped RNA Analysis

Pharmaceuticals
Following the success of mRNA vaccines against COVID-19, mRNA-based therapeutics have now become a great interest and potential. The development of this approach has been preceded by studies of modifications found on mRNA ribonucleotides that influence ...
Maciej Lukaszewicz
doaj   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source