Results 61 to 70 of about 813,296 (157)
Physiologia Plantarum, Volume 178, Issue 5, September/October 2026.ABSTRACT Genome‐wide association studies (GWAS) aim to identify loci associated with different traits, which could be evaluated in subsequent studies and later be prioritized in individual and seed stand selection. In trees, traits are measured at maturity or are only available after a long time, and juvenile‐mature correlations are often unknown ...
Mila Tost +8 more
wiley +1 more source
eLife, 2020 Eukaryotic 5’−3’ mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. In Caenorhabditis elegans, deficiency of DCAP-1/DCP1, the essential co-factor of the major cytoplasmic mRNA
Fivos Borbolis +10 more
doaj +1 more source
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, Volume 13, Issue 48, 28 August 2026.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Structural and Enzymatic Characterization of the Yeast mRNA Decapping Enzyme, Dcp2 [PDF]
, 2010 mRNA turnover represents a fundamental point of post-transcriptional control of gene expression in eukaryotes. Decapping is a highly regulated, irreversible step in mRNA decay and is involved in many different decay pathways.
Jones, Brittnee Noelle
core
General decapping activators target different subsets of inefficiently translated mRNAs [PDF]
, 2019 The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting PAT1, LSM1, or DHH1, or the DCP2 C-terminal ...
Wu, Chan +3 more
core +1 more source
PLoS Biology, 2020 RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I (RIG-
Kai Mao, Peter Breen, Gary Ruvkun
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source
The Role of Enzyme-Coactivator Interactions in the Regulation of mRNA Decapping [PDF]
, 2011 Messenger RNA degradation is a fundamental aspect of eukaryotic gene expression, regulation, and quality control. Removal of the 5' N7-methylguanosine (m7G) cap structure by the decapping enzyme Dcp2 is an irreversible step committing an mRNA to ...
Borja, Mark
core
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. [PDF]
PLoS ONE, 2017 C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) protein ...
Jonathan J Cherry +24 more
doaj +1 more source
New Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang +14 more
wiley +1 more source