Results 101 to 110 of about 477,117 (342)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
DUE DILIGENCE AND DECENT WORK. SPECIAL REFERENCE TO LABOUR LEGISLATION IN VALUE CHAINS
, 2023 Miriam Judit Gómez Romero
openalex +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Precarious Work: How Temporary Jobs and Subcontracting Undermine Women, Migrants, and All Workers’ Rights to Decent Work Worldwide [PDF]
, 2009 This document provides a number of case studies of US corporations’ use of precarious and contract labor to weaken unions and cut costs. Also describes the effects of these practices on the working conditions and labor rights of women and ...
International Labor Rights Forum
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Predictors of Decent Work Among Black Brazilians Workers [PDF]
Psico-USFThis study investigated the predictors of decent work for Black workers in Brazil, grounded in the Psychology of Working Theory (PWT). The relationships among marginalization, economic constraints, work volition, and racial microaggressions in the ...
Juliana Pereira Rodrigues Nunes +1 more
doaj +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Decent Work and the Informal Economy [PDF]
employment, governance, ILO, indicators, informal sector, representation, rights, social ...
Trebilcock, Anne
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Women Working in the Shadows: The Informal Economy and Export Processing Zones [PDF]
, 2010 A publication providing a description of women’s work in the world economy and the manner by which their rights are systematically violated. Suggests that the ILO Agenda for Decent Work and the recommendations of the UN Development Fund for Women be ...
Wick, Ingeborg
core +1 more source