Results 91 to 100 of about 1,927 (208)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

DECENT WORK AND COFFEE SECTOR: ARE THE COFFEE ESTATES IN KENYA COMPLYING WITH DECENT WORK IN PRODUCTION AND PRIMARY PROCESSING?

Apstract: Applied Studies in Agribusiness and Commerce
Coffee plays a big role in Kenya, it contributes to 30 percent of agricultural jobs and country’s exports. However, casual workers within coffee estates still get challenging employment conditions including long working hours, unfair wages, limited ...
Joseph Munyentwari Mbuta, Bett K Hillary, Rebecca Jerop   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The relationship between career adaptability, decent work, job satisfaction and burnout among psychiatrists: a cross-sectional study

BMC Psychiatry
Background The COVID-19 pandemic has led to a global increase in demand for mental health services, worsening the shortage of psychiatrists. As a result, psychiatrists have experienced decreased job satisfaction, diminished perceptions of decent work ...
Huaineng Wu, Simin Zhu, Luoyan Wang, Huibo Yuan, Bowen Xue, Hong Luo   +5 more
doaj   +1 more source

The impact of perceived organizational support on nurses' safety behavior: the sequential mediating roles of decent work perception and job embeddedness

Frontiers in Public Health
ObjectiveTo examine the sequential mediating role of decent work perception and job embeddedness of decent work perception and job embeddedness in the relationship between perceived organizational support and nurses' safety behavior.MethodsA multicenter ...
Huihua Tang, Qianming Xie, Chunyan Liao, Guowei Chen, Lili Zhang, Meifang Mo, Hangrui Zhang   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Decent work and nurses' work ability: A cross-sectional study of the mediating effects of perceived insider status and psychological well-being

International Journal of Nursing Studies Advances
Background: While the benefits of decent work—employment that respects fundamental human rights, ensures fair income, guarantees workplace security, and provides social protection for families—have recently gained scholarly attention regarding job ...
Heba Emad El-Gazar, Amira Mohammed Ali, Mona Shawer, Reham Moharam Serag, Mohamed Ali Zoromba   +4 more
doaj   +1 more source

Decent work and decent working hours in the world of modern technologies

, 2022
Where human work has been used for centuries, new technologies have been imposed. Systems of generating new information and configurations that help solve problematic issues without human factor interference are imposed to us. Is this good for humanity? Some people believe that artificial intelligence will destroy jobs and human labor.
openaire   +1 more source