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Annals of the New York Academy of Sciences, 2009
beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S Vicky, Tsoni, Gordon D, Brown
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beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S Vicky, Tsoni, Gordon D, Brown
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Variation in the Yak Dectin-1 Gene (CLEC7A)
DNA and Cell Biology, 2011C-type lectin domain family 7, member A (CLEC7A, dectin-1) plays an important role in antifungal immunity and belongs to the family of C-type lectin receptors. Variation in the extended exon 4-6 region of the yak dectin-1 gene (CLEC7A), which encodes the β-glucan recognition domain, was investigated using polymerase chain reaction-single strand ...
Guo, Yang +4 more
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The Biological Role of Dectin-1 in Immune Response
International Reviews of Immunology, 2007The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan.
Lina, Sun, Yong, Zhao
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A critical role of Dectin-1 in hypersensitivity pneumonitis
Inflammation Research, 2015Hypersensitivity pneumonitis (HP) is a pulmonary disease caused by repeated exposure to various aspiration antigens, including bacteria and fungi. Although TLRs are known to be required for the generation of HP triggered by bacteria, the significance of fungal receptors remains unclear. The present study aimed to investigate whether Dectin-1 and Dectin-
Mari, Higashino-Kameda +10 more
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Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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Dectin-1: a signalling non-TLR pattern-recognition receptor
Nature Reviews Immunology, 2005Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines.
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[Role of Dectin-1 in innate immunity].
Sheng li ke xue jin zhan [Progress in physiology], 2006Ce, Yang +2 more
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