Results 71 to 80 of about 333,665 (333)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation

Signals
Whilst balance disturbances are common in people with advanced Parkinson’s disease, it has not previously been possible to record vestibular evoked myogenic potentials (VEMPs), and thus otolithic function, during monopolar deep brain stimulation (DBS ...
Kim E. Hawkins, John Holden, Elodie Chiarovano, Simon J. G. Lewis, Ian S. Curthoys, Hamish G. MacDougall   +5 more
doaj   +1 more source

Human Sensation of Transcranial Electric Stimulation. [PDF]

, 2019
Noninvasive transcranial electric stimulation is increasingly being used as an advantageous therapy alternative that may activate deep tissues while avoiding drug side-effects. However, not only is there limited evidence for activation of deep tissues by
Richardson, Matthew, Sun, Shuping, Tran, Phillip, Xu, Yuchen, Zeng, Fan-Gang   +4 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Controlling the Error on Target Motion through Real-time Mesh Adaptation: Applications to Deep Brain Stimulation [PDF]

, 2017
We present an error-controlled mesh refinement procedure for needle insertion simulation and apply it to the simulation of electrode implantation for deep brain stimulation, including brain shift.
Audette, Michel, Bordas, Stéphane P. A., Bui, Huu Phuoc, Cotin, Stéphane, Courtecuisse, Hadrien, Tomar, Satyendra   +5 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Single-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke

Journal of Translational Medicine
Background In patients with ischemic stroke, the hippocampus is one of the most severely damaged regions of the brain; however, the optimal parameters for hippocampal deep brain stimulation in these patients remain unknown.
Xuyu Zhao, Yiyang Cao, Xiao Li, Peiru Wu, Jianxin Zhou, Qing Zou, Huanle Hong, Jingying Huang, Rabia Sultan, Jiao Wang   +9 more
doaj   +1 more source

Deep brain stimulation of posterior hypothalamic area for cluster headache

Cephalalgia Reports, 2018
Background: Deep brain stimulation of the posterior hypothalamic area is one of the neuromodulation treatments used for chronic cluster headache, but the number of published patients remains low.
Antti Huotarinen, Mikko Kallela, Ville Artto, Aki Laakso, Riku Kivisaari   +4 more
doaj   +1 more source

Physical therapy and deep brain stimulation in Parkinson’s Disease: Protocol for a pilot randomized controlled trial [PDF]

, 2018
Background Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson’s Disease (PD).
Duncan, Ryan P, Earhart, Gammon M, Garbutt, Jane M, Perlmutter, Joel S, Van Dillen, Linda R   +4 more
core   +2 more sources