Results 81 to 90 of about 324,009 (338)

Deep brain stimulation for dementias [PDF]

Neurosurgical Focus, 2018
OBJECTIVEThe aim of this article is to review the authors’ and published experience with deep brain stimulation (DBS) therapy for the treatment of patients with Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD).METHODSTwo targets are current topics of investigation in the treatment of AD and PDD, the fornix and the nucleus basalis of ...
David S. Xu, Francisco A. Ponce
openaire   +3 more sources

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun, Alpay Özcan, Fuat Kaan Aras, Evrim Bozdemir, Sibel Uğur İşeri, Koray Kırımtay, Arzu Karabay, Murat Gültekin, Nihan Hande Akçakaya, Orkhan Mammadov, Gülay Kır, Dilek İnce Günal, Neşe Tuncer, Fatma Betül Özdilek, Banu Özen Barut, Ercan Köse, Hülya Apaydın, Asuman Ali, Sultan Çağırıcı, Pınar Topaloğlu, Alp Dinçer, Zuhal Yapıcı   +21 more
wiley   +1 more source

Singing the Brain Electric [PDF]

, 2008
Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2008.Includes bibliographical references (p. [36]-[38]).Singing the Brain Electric Brain pacemakers, scientists have found,
Chua, Grace (Grace W. J.)
core  

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease

Nature Communications
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders.
Thomas S. Binns, Richard M. Köhler, Jojo Vanhoecke, Meera Chikermane, Moritz Gerster, Timon Merk, Franziska Pellegrini, Johannes L. Busch, Jeroen G. V. Habets, Alessia Cavallo, Jean-Christin Beyer, Bassam Al-Fatly, Ningfei Li, Andreas Horn, Patricia Krause, Katharina Faust, Gerd-Helge Schneider, Stefan Haufe, Andrea A. Kühn, Wolf-Julian Neumann   +19 more
doaj   +1 more source

Dopamine Dysregulation Syndrome and Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Neurology Research International, 2011
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical ...
Beatriz De la Casa-Fages, Francisco Grandas   +1 more
doaj   +1 more source

Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus

Brain Sciences, 2019
Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders.
Juan Carlos Baldermann, Lisa Hahn, Till A. Dembek, Sina Kohl, Jens Kuhn, Veerle Visser-Vandewalle, Andreas Horn, Daniel Huys   +7 more
doaj   +1 more source

Adverse Psychological Effects to Deep Brain Stimulation: Overturning the Question [PDF]

, 2014
Our invited contribution is a response to Mecacci, G., and W. F. G. Haselager. 2014. Stimulating the self: The influence of conceptual frameworks on reactions to deep brain stimulation.
Moratti, Sofia, Patterson, Dennis
core   +1 more source

Deep Brain Stimulation for Epilepsy [PDF]

Neuromodulation: Technology at the Neural Interface, 2009
Introduction. There is renewed interest in the use of electrical stimulation to control seizures in patients with medically refractory epilepsy. The evidence indicates that multiple nuclei are involved in the onset, spread, or termination of seizures. Establishing electrical stimulation parameters tailored to these nuclei that best control seizures is ...
Sean J. Nagel, Imad Najm
openaire   +3 more sources